Department of Dermatology and Venereology, Martin-Luther-University Halle-Wittenberg, Ernst-Kromayer-Strasse 5, Halle (Saale), Germany.
Arch Dermatol Res. 2013 Mar;305(2):91-8. doi: 10.1007/s00403-013-1318-9. Epub 2013 Feb 3.
Since the pathogenesis of psoriasis vulgaris is now understood as a T cell mediated systemic auto-immune disease, the awareness for the potential systemic implications of the chronic active inflammation has grown. By evaluation of patient registries and study data, several complexes of comorbidities could be identified in recent years, albeit not all of them being clinically relevant. Comorbidity in this context will be defined as two or more diagnostically distinguished medical conditions existing simultaneously, but without a causal link. Nevertheless, there is some strong indication for pathogenetic link between some specified comorbidities and psoriasis at molecular and immunological level. The need for an interdisciplinary assessment of the potential interrelation is obvious. In order to detect the individual risk for comorbidities in patients with moderate to severe psoriasis and to recommend the course of action, a checklist has been developed at an interdisciplinary level that is reduced to the quintessential points for the use in daily practice.
由于目前人们已经了解到寻常型银屑病的发病机制是一种 T 细胞介导的系统性自身免疫性疾病，因此人们已经意识到这种慢性活动性炎症可能会引发全身性疾病。通过对患者登记和研究数据的评估，近年来已经确定了几种复杂的合并症，但并非所有这些合并症都具有临床意义。在此上下文中，合并症将被定义为两种或更多种同时存在的经诊断区分的医疗状况，但没有因果关系。然而，在分子和免疫学水平上，某些特定的合并症与银屑病之间存在一些强有力的发病机制联系的迹象。因此，显然需要进行跨学科评估以确定它们之间潜在的相互关系。为了检测中重度银屑病患者的合并症的个体风险，并建议采取相应的治疗措施，我们已经制定了一份跨学科的检查表，该检查表已简化为在日常实践中使用的要点。
