Grozdev Ivan, Korman Neil, Tsankov Nikolai
Department of Dermatology and Venereology, Medical Faculty, Medical University-Sofia, 1 Saint Georgi Sofiiski Boulevard, 1431 Sofia, Bulgaria.
Murdough Family Center for Psoriasis, University Hospitals Case Medical Center, Cleveland, Ohio.
Clin Dermatol. 2014 May-Jun;32(3):343-50. doi: 10.1016/j.clindermatol.2013.11.001. Epub 2013 Nov 23.
Psoriasis is an inflammatory immune-mediated disease that affects the skin and has pathogenic effects with systemic impact. The relationship between psoriasis and comorbidities remains controversial. The hypothesis of a causative role of psoriasis in its cardiovascular and metabolic comorbidities is based on pathophysiologic concepts establishing a link between chronic inflammation in psoriasis, endothelial dysfunction, formation of atherosclerotic plaques, and the different compounds of metabolic syndrome. Psoriasis management has to be multidisciplinary. It implicates identification and treatment of psychological disorders, addictions, and associated cardiovascular and metabolic diseases, together with improvement of quality of life of patients.
银屑病是一种炎症性免疫介导疾病，会影响皮肤，并具有全身性影响的致病作用。银屑病与合并症之间的关系仍存在争议。银屑病在其心血管和代谢合并症中起因果作用的假说基于病理生理学概念，这些概念在银屑病中的慢性炎症、内皮功能障碍、动脉粥样硬化斑块形成以及代谢综合征的不同组成部分之间建立了联系。银屑病的管理必须是多学科的。这意味着要识别和治疗心理障碍、成瘾以及相关的心血管和代谢疾病，同时提高患者的生活质量。
