Department of Chemical Hazards and Genetic Toxicology, Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland.
Occup Environ Med. 2013 Jun;70(6):365-71. doi: 10.1136/oemed-2012-100979. Epub 2013 Feb 1.
Changes in enzymatic antioxidant activity are frequently observed in workers occupationally exposed to lead. Few studies have investigated the influence of lead on the non-enzymatic antioxidant system. The aim of our study was to assess the influence of occupational exposure to lead on the plasma concentration of two hydrophobic forms of vitamin E: α-tocopherol and γ-tocopherol.
A sample of 401 healthy men, aged 19-62, participated in the study. In total, 340 of these subjects were employed at the Mine and Metallurgical Plant in southern Poland. The workers who were occupationally exposed to lead were divided into quartiles (groups of 85 subjects). The lead concentrations in the blood of the subjects in the control group and in the lead exposure quartiles correspond to the following ranges: 10-72 μg/l (control group); 82-206 μg/l (Q1); 209-308 μg/l (Q2); 308-394 μg/l (Q3) and 395-644 μg/l (Q4), respectively.
Significant differences were observed only for the plasma concentration of γ-tocopherol, which differed between the control group and Q1 (by 24.1%, p=0.0368), between Q1 and Q3 (by -18.8%, p=0.0115) and between Q1 and Q4 (by -25.7%, p=0.0002). Multiple linear regression analysis showed that the statistically significant, predictive properties of the γ-tocopherol plasma concentration were as follows: triglycerides (β=0.440)> age (β=0.131)> whole cholesterol (β=0.117)> blood lead concentration (β=-0.108). For α-tocopherol, significant prognostic properties were triglycerides and total cholesterol (β=0.485 and β=0.399, respectively).
Occupational exposure to lead is strongly correlated with the concentration of γ-tocopherol but not α-tocopherol.
职业性铅暴露的工人常出现酶抗氧化活性的变化。很少有研究调查铅对非酶抗氧化系统的影响。我们的研究目的是评估职业性铅暴露对两种疏水性维生素 E 形式：α-生育酚和γ-生育酚的血浆浓度的影响。
本研究纳入了 401 名年龄在 19-62 岁的健康男性。其中 340 名受试者在波兰南部的一家矿山和冶金厂工作。职业性铅暴露的工人被分为四组（每组 85 名受试者）。对照组和铅暴露四组受试者的血铅浓度分别为 10-72μg/l（对照组）；82-206μg/l（Q1）；209-308μg/l（Q2）；308-394μg/l（Q3）和 395-644μg/l（Q4）。
仅γ-生育酚的血浆浓度存在显著差异，对照组与 Q1 之间（相差 24.1%，p=0.0368）、Q1 与 Q3 之间（相差-18.8%，p=0.0115）以及 Q1 与 Q4 之间（相差-25.7%，p=0.0002）存在差异。多元线性回归分析表明，γ-生育酚血浆浓度具有统计学意义的预测特性，如下：甘油三酯（β=0.440）>年龄（β=0.131）>总胆固醇（β=0.117）>血铅浓度（β=-0.108）。对于α-生育酚，具有显著预测特性的是甘油三酯和总胆固醇（β=0.485 和 β=0.399）。
职业性铅暴露与γ-生育酚浓度密切相关，但与α-生育酚浓度无关。
