Dobrakowski Michał, Zalejska-Fiolka Jolanta, Wielkoszyński Tomasz, Świętochowska Elżbieta, Kasperczyk Sławomir
Med Pr. 2014;65(4):443-51. doi: 10.13075/mp.5893.00025.
The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and non-enzymatic antioxidant concentrations in serum and plasma.
The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level - PbB = 20-39.9 µg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 µg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 µ/dl and 2.5 µg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated.
Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group.
Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system.
非酶抗氧化剂，如尿酸、白蛋白、胆红素和α-生育酚，在铅中毒中的作用仍不明确。因此，本研究的目的是探讨职业性铅暴露与血清和血浆中非酶抗氧化剂浓度之间的关联。
研究对象为278名铅锌厂健康男性员工，其中129名工人被归类为低铅暴露（血铅水平 - PbB = 20 - 39.9 μg/dl），149名工人被归类为高铅暴露（PbB = 40 - 59.8 μg/dl）。对照组由73名健康男性行政人员组成。该组中无人的血铅水平或锌原卟啉（ZPP）水平高于正常水平，正常水平分别为10 μg/dl和2.5 μg/g血红蛋白。除了PbB和ZPP水平外，还测定了血清尿酸（UA）、白蛋白、白蛋白的巯基和胆红素水平。还评估了血浆铁还原能力（FRAP）和血浆α-生育酚水平。
与对照组相比，所检查亚组中的铅暴露指标显著升高。两个亚组的血清尿酸水平均显著升高，尤其是高暴露组。与对照组相比，高暴露组的血清胆红素浓度显著升高，而低暴露组仅显示出不显著的升高趋势。相比之下，与对照组相比，所检查亚组的血浆铁还原能力没有显著提高。然而，与对照组相比，暴露亚组中的白蛋白、白蛋白的巯基和α-生育酚水平显著降低。
职业性铅暴露会干扰血液非酶抗氧化系统。
