INSERM, U1065, Centre Méditerranéen de Médecine Moléculaire, Microbial Toxins in Host-Pathogen Interactions, C3M, Université de Nice-Sophia-Antipolis, UFR Médecine, 06204 Nice, France.
Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a013573. doi: 10.1101/cshperspect.a013573.
Bacterial pathogens produce protein toxins to influence host-pathogen interactions and tip the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify host-specific targets through posttranslational modifications (PTMs) or noncovalent interactions that may inhibit or activate host cell physiology to benefit the pathogen. Recent advances have identified new PTMs and host targets for toxin action. Understanding the mechanisms of toxin action provides a basis to develop vaccines and therapies to combat bacterial pathogens and to develop new strategies to use toxin derivatives for the treatment of human disease.
细菌病原体产生蛋白毒素以影响宿主-病原体相互作用，并使这些相互作用的结果有利于病原体。蛋白毒素通过可能抑制或激活宿主细胞生理以有利于病原体的翻译后修饰（PTMs）或非共价相互作用来修饰宿主特异性靶标。最近的进展确定了毒素作用的新 PTM 和宿主靶标。了解毒素作用的机制为开发疫苗和疗法以对抗细菌病原体以及开发利用毒素衍生物治疗人类疾病的新策略提供了基础。
