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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Charnock J S, Simonson L P

Department of Pharmacology, University of Alberta, Edmonton, Canada.

Comp Biochem Physiol B. 1977;58(4):381-7. doi: 10.1016/0305-0491(77)90185-7.

(Na+ + K+)-ATPase from homeotherms and poikilotherms demonstrate non-linear thermal dependence for ATP hydrolysis. Apparent energies of activation from crab nerve preparations are less than those of brain or kidney preparations from beef, rabbit, sheep or ground squirrel. 2. Crab nerve (Na+ + K+)-ATPase is less sensitive to inhibition by ouabain than that from beef or ground squirrel; lower rates of [3H]-ouabain binding and reduced amount of drug bound at equilibrium are found. 3. K+-activated acyl-phosphatase is similar in all preparations. 4. Fluorescence polarization of 12-AS labelled membranes demonstrate greater mobility of crab nerve lipids compared to beef brain which has a thermal transition at 20-25 degrees C. Crab nerve is linear in this range.

恒温动物和变温动物的（钠+钾）-ATP酶对ATP水解表现出非线性热依赖性。蟹神经制剂的表观活化能低于牛肉、兔子、绵羊或地松鼠的脑或肾制剂。2. 蟹神经（钠+钾）-ATP酶对哇巴因抑制的敏感性低于牛肉或地松鼠的；发现[3H]-哇巴因结合率较低且平衡时结合的药物量减少。3. 钾激活的酰基磷酸酶在所有制剂中相似。4. 与在20-25摄氏度有热转变的牛脑相比，12-AS标记膜的荧光偏振表明蟹神经脂质的流动性更大。蟹神经在这个范围内呈线性。

Charnock J S, Simonson L P

Department of Pharmacology, University of Alberta, Edmonton, Canada.

Comp Biochem Physiol B. 1977;58(4):381-7. doi: 10.1016/0305-0491(77)90185-7.

(Na+ + K+)-ATPase from homeotherms and poikilotherms demonstrate non-linear thermal dependence for ATP hydrolysis. Apparent energies of activation from crab nerve preparations are less than those of brain or kidney preparations from beef, rabbit, sheep or ground squirrel. 2. Crab nerve (Na+ + K+)-ATPase is less sensitive to inhibition by ouabain than that from beef or ground squirrel; lower rates of [3H]-ouabain binding and reduced amount of drug bound at equilibrium are found. 3. K+-activated acyl-phosphatase is similar in all preparations. 4. Fluorescence polarization of 12-AS labelled membranes demonstrate greater mobility of crab nerve lipids compared to beef brain which has a thermal transition at 20-25 degrees C. Crab nerve is linear in this range.

恒温动物和变温动物的（钠+钾）-ATP酶对ATP水解表现出非线性热依赖性。蟹神经制剂的表观活化能低于牛肉、兔子、绵羊或地松鼠的脑或肾制剂。2. 蟹神经（钠+钾）-ATP酶对哇巴因抑制的敏感性低于牛肉或地松鼠的；发现[3H]-哇巴因结合率较低且平衡时结合的药物量减少。3. 钾激活的酰基磷酸酶在所有制剂中相似。4. 与在20-25摄氏度有热转变的牛脑相比，12-AS标记膜的荧光偏振表明蟹神经脂质的流动性更大。蟹神经在这个范围内呈线性。