与大流行 2009 年 H1N1 流感病毒引起的肺炎相关的临床预测因素。
Clinical factors predictive of pneumonia caused by pandemic 2009 H1N1 influenza virus.
机构信息
Department of Medicine, Thungsong Hospital, Walailak University School of Medicine, Nakhon Si Thammarat, Thailand.
出版信息
Am J Trop Med Hyg. 2013 Mar;88(3):461-3. doi: 10.4269/ajtmh.12-0132. Epub 2013 Feb 4.
Pneumonia was the most common cause of death during the 2009 pandemic H1N1 influenza virus infection. Clinical risk factors for pneumonia caused by this virus are limited. We enrolled consecutive patients treated at the H1N1 Clinic in Thungsong Hospital in Nakhon Si Thammarat, Thailand, during June-December 2009 who had positive polymerase chain reaction results for H1N1 virus. Clinical features for patients given a diagnosis with and without pneumonia were studied. There were 441 patients with positive polymerase chain reaction results for H1N1 virus. Of these patients, 51 (11.56%) had pneumonia. Three independent clinical factors for H1N1 pneumonia were myalgia, dyspnea, and an absolute neutrophil count > 7,700 cells/μL. Adjusted odds ratios (95% confidence intervals) for these three variables were 0.413 (0.173-0.988), 2.625 (1.230-5.604), and 4.475 (1.882-10.644), respectively. Clinical features may be a useful tool for predicting risk for pneumonia caused by H1N1 virus.
在 2009 年甲型 H1N1 流感病毒感染期间，肺炎是最常见的死亡原因。导致这种病毒引起肺炎的临床危险因素有限。我们连续招募了 2009 年 6 月至 12 月在泰国那空是贪玛叻府 Thungsong 医院甲型 H1N1 诊所接受治疗且聚合酶链反应（PCR）结果为甲型 H1N1 病毒阳性的患者。研究了患有和不患有肺炎的患者的临床特征。有 441 例患者的 PCR 结果为甲型 H1N1 病毒阳性。其中 51 例（11.56%）患有肺炎。甲型 H1N1 肺炎的三个独立临床因素为肌痛、呼吸困难和绝对中性粒细胞计数＞7700 个/μL。这三个变量的校正比值比（95%置信区间）分别为 0.413（0.173-0.988）、2.625（1.230-5.604）和 4.475（1.882-10.644）。临床特征可能是预测甲型 H1N1 病毒引起肺炎风险的有用工具。
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