Emeritus Professor of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
Clin Infect Dis. 2013 May;56(10):1458-65. doi: 10.1093/cid/cit048. Epub 2013 Feb 5.
In several prior articles I have attempted to analyze and simplify the subject of immunological functions induced by vaccination that correlate with protection against later exposure to pathogens. Other authors have also written on the subject, and recently we jointly proposed terminology to bring some semantic clarity to the field. The generalization that vaccine-induced antibodies prevent acquisition whereas cellular immune functions clear infection still holds true, but that simple distinction becomes blurred in many instances. Specific antibody and cellular responses are multiple and redundant, so that vaccines for some pathogens protect through more than 1 immune function. Thus, this article aims in the direction opposite to simplicity to depict the complexity of correlates, or rather the complexity of mechanistic immune functions that contribute to protection. Nonmechanistic correlates that are practically useful but not truly protective will be mentioned in passing.
在之前的几篇文章中，我试图分析和简化疫苗接种诱导的免疫功能与预防后续病原体暴露之间的关系。其他作者也写过相关内容，最近我们共同提出了术语，以使该领域具有一定的语义清晰度。疫苗诱导的抗体预防获得性感染，而细胞免疫功能清除感染的这种概括仍然成立，但在许多情况下，这种简单的区别变得模糊。特异性抗体和细胞反应是多样且冗余的，因此，针对某些病原体的疫苗通过多种免疫功能发挥作用。因此，本文旨在背离简单性，描述相关性的复杂性，或者更确切地说，是有助于保护的机制性免疫功能的复杂性。在实际中有用但并非真正具有保护作用的非机制性相关性将被顺带提及。
