Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
J Physiol Pharmacol. 2012 Dec;63(6):691-6.
The role of heat shock proteins and anti-HSP 60/65 antibodies in atherogenesis has been widely described in the literature, but the participation of these molecules in the pathogenesis of diabetic macroangiopathy has not been extensively investigated. 30 patients with type 2 diabetes complicated with macroangiopathy of the lower extremities in the intermittent claudication stage. The control group (n=18) consisted of healthy volunteers of corresponding age. Levels of anti-HSP 60/65 antibodies, von Willebrand factor (vWF) and hsCRP in blood serum were measured. We also assessed static effort based on isometric contraction lasting until full fatigue. In patients with lower limb ischemia in diabetic macroangiopathy, a positive correlation between anti-HSP 60/65 antibodies and von Willebrand factor levels in blood serum was found (R=0.543, p<0.05). Concentrations of anti-HSP 60/65 antibodies were higher than in the control group, but not statistically significant (44.77±55.00 vs. 26.09±13.85; NS). The ongoing disease process contributed statistically significantly to the strength of the quadriceps muscle of the thigh (21.47 vs. 27.82 for the right limb, and 20.27 vs. 28.33 for the left limb; p<0.05). Increased concentrations of anti-HSP 60/65 antibodies in blood serum suggests their involvement in the pathogenesis of diabetic macroangiopathy and correlates with the parameters of endothelial cell damage. In patients with type 2 diabetes complicated with atherosclerotic changes, a statistically significant reduction in lower limb muscle strength was found compared with the control group.
热休克蛋白和抗 HSP60/65 抗体在动脉粥样硬化形成中的作用在文献中已有广泛描述，但这些分子在糖尿病大血管病变发病机制中的作用尚未得到广泛研究。30 例 2 型糖尿病合并下肢大血管病变间歇性跛行期患者。对照组（n=18）由年龄相应的健康志愿者组成。检测血清中抗 HSP60/65 抗体、血管性血友病因子（vWF）和 hsCRP 的水平。我们还评估了基于等长收缩至完全疲劳的静态用力。在下肢缺血的糖尿病大血管病变患者中，发现血清中抗 HSP60/65 抗体与 vWF 水平呈正相关（R=0.543，p<0.05）。抗 HSP60/65 抗体浓度高于对照组，但无统计学意义（44.77±55.00 与 26.09±13.85；NS）。正在进行的疾病过程对股四头肌的力量有统计学显著影响（右侧为 21.47，左侧为 27.82；p<0.05）。血清中抗 HSP60/65 抗体浓度的升高提示其参与糖尿病大血管病变的发病机制，并与内皮细胞损伤的参数相关。与对照组相比，2 型糖尿病合并动脉粥样硬化变化的患者下肢肌肉力量显著降低。
