Medical Research Council-University of Glasgow Centre for Virus Research, Institute of Infection, Inflammation and Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
J Virol. 2013 Apr;87(8):4768-71. doi: 10.1128/JVI.03379-12. Epub 2013 Feb 6.
Influenza A viruses are characterized by their ability to evade host immunity, even in vaccinated individuals. To determine how prior immunity shapes viral diversity in vivo, we studied the intra- and interhost evolution of equine influenza virus in vaccinated horses. Although the level and structure of genetic diversity were similar to those in naïve horses, intrahost bottlenecks may be more stringent in vaccinated animals, and mutations shared among horses often fall close to putative antigenic sites.
甲型流感病毒的特点是能够逃避宿主免疫，即使在接种疫苗的个体中也是如此。为了确定先前的免疫如何在体内塑造病毒多样性，我们研究了接种疫苗的马体内和体内流感病毒的进化。尽管遗传多样性的水平和结构与未感染的马相似，但接种动物体内的瓶颈可能更为严格，并且马之间共享的突变通常接近假定的抗原位点。
