Angelini G, Rantuccio F, Meneghini C L
Department of Dermatology of the University, Bari, Italy.
Contact Dermatitis. 1975;1(2):81-7. doi: 10.1111/j.1600-0536.1975.tb05332.x.
The incidence of contact allergy to 63 substances, including active principles and excipients used in a variety of topical preparations, has been studied by patch testing in 306 patients being treated conservatively for stasis dermatitis with or without ulceration. Positive reactions to one or more test compounds were recorded in 177 patients. The main offenders among drugs were neomycin, sulphonamide and promethazine; among the excipients, they were parabens, lanolins and benzoyl peroxide. Frequent reactions were observed to certain substances of the 'para' group, benzocaine, diaminodiphenylmethane, aniline and paraphenylendiamine, with the first three acting mainly as indicators of cross-sensitization. The extension and spread of allergic dermatitis can also be produced by drugs administered systematically. Recognition of the allergens responsible for allergic contact dermatitis arising at the lower leg site is a necessary condition if chronicity and spread of the dermatitis are to be prevented. For the same reason it is important to restrict topical applications to non-allergic substances.
通过斑贴试验，对306例正在接受保守治疗的伴有或不伴有溃疡的淤积性皮炎患者，研究了对63种物质（包括各种外用制剂中使用的活性成分和辅料）的接触性过敏发生率。177例患者对一种或多种测试化合物出现阳性反应。药物中主要的致敏原是新霉素、磺胺类药物和异丙嗪；辅料中则是对羟基苯甲酸酯、羊毛脂和过氧化苯甲酰。观察到对某些“对”类物质、苯佐卡因、二氨基二苯甲烷、苯胺和对苯二胺有频繁反应，前三种主要作为交叉致敏的指标。系统性给药的药物也可引起过敏性皮炎的扩展和蔓延。如果要预防皮炎的慢性化和蔓延，识别导致小腿部位过敏性接触性皮炎的过敏原是必要条件。出于同样的原因，将局部用药限制在非过敏性物质上很重要。
