Degreef H, Dooms-Goossens A, Gladys K
Phlebologie. 1986 Jan-Mar;39(1):135-43.
Patients with leg ulcers or varicose eczema suffer much more often from contact eczema due to the local application of pharmaceutical preparations than patients suffering from other dermatological problems (even those of eczematous origin). This contact allergy may concern not only the active ingredient but also the excipient, the preservative, or even the perfume. In all cases of leg ulcers, of varicose eczema, but also of badly healed ulcers, epicutaneous tests should be carried out with all the components of the pharmaceutical preparations concerned. Moreover, the pharmaceutical industry really must perfect non-allergenic preparations.
与患有其他皮肤病问题（甚至是湿疹源性问题）的患者相比，腿部溃疡或静脉曲张性湿疹患者因局部应用药物制剂而患接触性湿疹的情况要频繁得多。这种接触性过敏不仅可能涉及活性成分，还可能涉及辅料、防腐剂，甚至香料。对于所有腿部溃疡、静脉曲张性湿疹以及愈合不良的溃疡病例，均应对相关药物制剂的所有成分进行皮肤试验。此外，制药行业确实必须完善无过敏性的制剂。
