职业接触极低频磁场与神经退行性疾病：荟萃分析。
Occupational exposure to extremely low-frequency magnetic fields and neurodegenerative disease: a meta-analysis.
机构信息
Department of Epidemiology, University of California-Los Angeles (UCLA) Fielding School of Public Health, Los Angeles, CA, USA.
出版信息
J Occup Environ Med. 2013 Feb;55(2):135-46. doi: 10.1097/JOM.0b013e31827f37f8.
OBJECTIVE
Previous studies reported associations of occupational electric and magnetic fields (MF) with neurodegenerative diseases (NDDs). Results differ between studies using proxy exposure based on occupational titles and estimated MF levels. We conducted a meta-analysis of occupational MF NDD, primarily Alzheimer disease (AD), and motor neuron diseases (MNDs) studies.
METHODS
We identified 42 peer-reviewed publications and focused our analysis on study characteristics, exposure metrics, and publication bias.
RESULTS
We found weak associations for occupational MF exposure proxies with AD and MND. Motor neuron disease risk was associated with occupational titles, whereas AD risk was associated with estimated MF levels. Results varied in study design, with dissimilar variation across diseases.
CONCLUSIONS
Our results do not support MF as the explanation for observed associations between occupational titles and MND. Disease misclassification, particularly for AD, and imprecise exposure assessment affected most studies.
目的
先前的研究报告了职业电场和磁场（MF）与神经退行性疾病（NDD）之间的关联。使用基于职业头衔和估计 MF 水平的代理暴露进行的研究结果存在差异。我们对职业 MF NDD 进行了荟萃分析，主要是阿尔茨海默病（AD）和运动神经元疾病（MND）的研究。
方法
我们确定了 42 篇同行评审出版物，并重点分析了研究特征、暴露指标和发表偏倚。
结果
我们发现职业 MF 暴露代理与 AD 和 MND 之间存在微弱关联。运动神经元疾病的风险与职业头衔有关，而 AD 的风险与估计的 MF 水平有关。研究设计的结果存在差异，疾病之间的差异也不同。
结论
我们的结果不支持 MF 是职业头衔与 MND 之间观察到的关联的解释。疾病分类不当，特别是 AD，以及暴露评估不精确，影响了大多数研究。
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