基因组范围内拷贝数变异分析在对马立克氏病易感性不同的近交系鸡中的应用。

Department of Animal & Avian Sciences, University of Maryland, College Park, Maryland 20742, USA.

G3 (Bethesda). 2013 Feb;3(2):217-23. doi: 10.1534/g3.112.005132. Epub 2013 Feb 1.

Breeding of genetically resistant chickens to Marek's disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNVs were found in four lines of chickens, and 28 were potentially involved in immune response and cell proliferation, etc. Importantly, two CNVs related with MD resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may lead to better strategies for genetic improvement of disease resistance in poultry.

培育对马立克氏病（MD）具有遗传抗性的鸡是家禽健康的重要策略。为了找到对 MD 具有遗传抗性的遗传标记，对近交 MD 抗性和易感鸡系进行了拷贝数变异（CNV）分析。在四个鸡系中发现了 45 个 CNV，其中 28 个可能与免疫反应和细胞增殖等有关。重要的是，与 MD 抗性相关的两个 CNV 被传递到对 MD 易感性不同的后代重组近交系中。我们的研究结果可能为家禽疾病抗性的遗传改良提供更好的策略。