《乳腺癌根治术后克罗地亚女性的生活质量：一项单中心横断面研究》。
The quality of life of Croatian women after mastectomy: a cross-sectional single-center study.
机构信息
Department of Surgery, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Department of Surgery, University Hospital Osijek, Huttlerova 4, 31000, Osijek, Croatia.
出版信息
BMC Public Health. 2018 Aug 10;18(1):999. doi: 10.1186/s12889-018-5929-0.
BACKGROUND
Measuring the quality of life (QoL) of women with breast cancer is an important aspect of measuring treatment success. In Croatia, no QoL studies have been carried out with a focus on patients after mastectomy. The aim of this study was to examine QoL 1 month and 1 year after mastectomy.
METHODS
This cross-sectional single-center study of quality of life was conducted in 101 patients, 50 of whom had undergone a mastectomy 1 month prior, and 51 of whom had undergone a mastectomy 1 year prior. The study was conducted from July 2015 to June 2016. The questionnaires used in the study were developed by the European Organisation for Research and Treatment of Cancer (EORTC). The questionnaire EORTC QLQ-C30 assesses the QoL of cancer patients, and the questionnaire EORTC QLQ-BR23 is a disease-specific breast cancer module. A chi square test, Fisher's exact test, Kolmogorov-Smirnov test, Student's t-test and Mann-Whitney U test were performed in the statistical analysis using the statistical program SPSS (Inc. Released 2008. SPSS Statistics for Windows, Version 17.0. Chicago: SPSS Inc.).
RESULTS
Patients who had undergone a mastectomy a year earlier placed a higher value on their health state than did those who had undergone a mastectomy a month earlier. The most affected values of functional status on the EORTC QLQ-C30 scale were emotional functioning (37.5 [95% CI 33.3-61.6]) and sexual functioning (16.67 [95% CI 0-33.3]) 1 month and 1 year after mastectomy, respectively. The most affected symptoms on the EORTC QLQ-C30 scale were hair loss 66.67 [95% CI 33.3-100]) and fatigue 33.33 [95% CI 24-44]) 1 month and 1 year after mastectomy, respectively.
CONCLUSION
In our study, both functional and symptom scales were more affected in women 1 month after mastectomy. QoL was considerably improved in women 1 year after the surgery compared to 1 month after mastectomy. The results of this study could contribute to the public awareness of the QoL of breast cancer patients.
背景
衡量乳腺癌女性的生活质量（QoL）是衡量治疗成功的一个重要方面。在克罗地亚，没有专门针对乳房切除术患者的 QoL 研究。本研究的目的是检查乳房切除术 1 个月和 1 年后的 QoL。
方法
这是一项横断面单中心研究，共纳入 101 例患者，其中 50 例在 1 个月前接受乳房切除术，51 例在 1 年前接受乳房切除术。该研究于 2015 年 7 月至 2016 年 6 月进行。研究中使用的问卷由欧洲癌症研究与治疗组织（EORTC）开发。问卷 EORTC QLQ-C30 评估癌症患者的生活质量，问卷 EORTC QLQ-BR23 是一种特定于疾病的乳腺癌模块。在统计分析中使用统计程序 SPSS（Inc. 发布 2008 年。SPSS 统计软件 for Windows，版本 17.0。芝加哥：SPSS Inc.）进行了卡方检验、Fisher 确切检验、Kolmogorov-Smirnov 检验、学生 t 检验和曼-惠特尼 U 检验。
结果
1 年前接受乳房切除术的患者对自己的健康状况评价高于 1 个月前接受乳房切除术的患者。EORTC QLQ-C30 量表上功能状态受影响最大的分值分别为情绪功能（37.5[95%CI 33.3-61.6]）和性功能（16.67[95%CI 0-33.3]），分别为乳房切除术 1 个月和 1 年后。EORTC QLQ-C30 量表上受影响最大的症状分别为脱发 66.67[95%CI 33.3-100]）和疲劳 33.33[95%CI 24-44]），分别为乳房切除术 1 个月和 1 年后。
结论
在我们的研究中，乳房切除术 1 个月后的女性在功能和症状量表上受影响更大。与乳房切除术 1 个月后相比，手术后 1 年女性的生活质量有了显著改善。本研究的结果可能有助于提高公众对乳腺癌患者生活质量的认识。
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