介孔硅纳米粒子的金属锁纳米门实现 pH 响应性双重载药。
pH-responsive dual cargo delivery from mesoporous silica nanoparticles with a metal-latched nanogate.
机构信息
Department of Chemistry and Biochemistry, California NanoSystems Institute, University of California, Los Angeles, California 90095, United States.
出版信息
Inorg Chem. 2013 Feb 18;52(4):2044-9. doi: 10.1021/ic3024265. Epub 2013 Feb 7.
Abstract
A nanogate composed of two iminodiacetic acid (IDA) molecules and a metal ion latch was designed, synthesized, and assembled on mesoporous silica nanoparticles. This gating mechanism is capable of storing and releasing metal ions and molecules trapped in the pores. Pore openings derivatized with IDA can be latched shut by forming a bis-IDA chelate complex with a metal ion. This system was tested by loading with Hoechst 33342 as the probe cargo molecule, and latching with cobalt, nickel, or calcium metal ions. No cargo release was observed in a neutral aqueous environment, but both cargoes were delivered after acid stimulation and/or the addition of a competitively binding ligand.
摘要
设计、合成并组装了一种由两个亚氨基二乙酸（IDA）分子和一个金属离子闩锁组成的纳米门，用于介孔硅纳米粒子。这种门控机制能够存储和释放被困在孔内的金属离子和分子。用 IDA 衍生的孔口可以通过与金属离子形成双 IDA 螯合物复合物而关闭。该系统通过负载 Hoechst 33342 作为探针货物分子，并使用钴、镍或钙离子进行闩锁进行了测试。在中性水性环境中未观察到货物释放，但在酸刺激和/或添加竞争结合配体后，均实现了货物的释放。
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本文引用的文献
1
Critical Considerations in the Biomedical Use of Mesoporous Silica Nanoparticles.
J Phys Chem Lett. 2012 Feb 2;3(3):364-74. doi: 10.1021/jz2013837. Epub 2012 Jan 18.
2
Measurement of Uptake and Release Capacities of Mesoporous Silica Nanoparticles Enabled by Nanovalve Gates.
J Phys Chem C Nanomater Interfaces. 2011 Oct 13;115(40):19496-19506. doi: 10.1021/jp2047147.
3
Mesostructured chitosan-silica hybrid as a biodegradable carrier for a pH-responsive drug delivery system.
Dalton Trans. 2012 Apr 28;41(16):5038-44. doi: 10.1039/c2dt12347a. Epub 2012 Mar 1.
4
Mesoporous silica nanoparticles in biomedical applications.
Chem Soc Rev. 2012 Apr 7;41(7):2590-605. doi: 10.1039/c1cs15246g. Epub 2012 Jan 3.
5
Synthesis of Nanoporous Iminodiacetic Acid Sorbents for Binding Transition Metals.
Inorg Chem Commun. 2009 Apr 1;12(4):312-315. doi: 10.1016/j.inoche.2009.02.003.
6
Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine.
Acc Chem Res. 2011 Oct 18;44(10):903-13. doi: 10.1021/ar200018x. Epub 2011 Jun 15.
7
pH-operated nanopistons on the surfaces of mesoporous silica nanoparticles.
J Am Chem Soc. 2010 Sep 22;132(37):13016-25. doi: 10.1021/ja105371u.
8
Controlled delivery using oligonucleotide-capped mesoporous silica nanoparticles.
Angew Chem Int Ed Engl. 2010 Sep 24;49(40):7281-3. doi: 10.1002/anie.201001847.
9
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
J Am Chem Soc. 2010 Sep 15;132(36):12690-7. doi: 10.1021/ja104501a.
10
Mesoporous silica nanoparticles for intracellular controlled drug delivery.
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