狒狒正常和低脑血流状态下氙增强计算机断层扫描与[14C]碘安替比林的比较

Xenon-enhanced computed tomography compared with [14C]iodoantipyrine for normal and low cerebral blood flow states in baboons.

作者信息

Wolfson S K, Clark J, Greenberg J H, Gur D, Yonas H, Brenner R P, Cook E E, Lordeon P A

机构信息

Department of Neurological Surgery, University of Pittsburgh, Pennsylvania.

出版信息

Stroke. 1990 May;21(5):751-7. doi: 10.1161/01.str.21.5.751.

DOI:10.1161/01.str.21.5.751

PMID:2339455

Abstract

The correlation between the acute, invasive diffusible [14C]iodoantipyrine technique for cerebral blood flow and the noninvasive xenon-enhanced computed tomographic method has been assessed by simultaneous measurements in the baboon. Blood flows in small tissue volumes (about 0.125 cm3) were directly compared in normal and low flow states. These studies demonstrate a statistically significant association between the two methods (p less than 0.001). Similar correlations were obtained by both the Kendall (tau) and the Spearman (r) methods (r = 0.67 to 0.92, n greater than or equal to 19 for each study). The problems and limitations of such correlations are discussed.

摘要

通过在狒狒身上同时进行测量，评估了用于测量脑血流量的急性、侵入性可扩散[14C]碘安替比林技术与非侵入性氙增强计算机断层扫描方法之间的相关性。在正常和低流量状态下，直接比较了小组织体积（约0.125立方厘米）中的血流量。这些研究表明，两种方法之间存在统计学上的显著关联（p小于0.001）。通过肯德尔（tau）法和斯皮尔曼（r）法都得到了相似的相关性（r = 0.67至0.92，每项研究n大于或等于19）。讨论了这种相关性存在的问题和局限性。