高剂量围病变注射鹿蹄草提取物治疗皮肤鳞状细胞癌的持久反应——病例报告。
Durable response of cutaneous squamous cell carcinoma following high-dose peri-lesional injections of Viscum album extracts--a case report.
机构信息
Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke, Freiburg, Germany.
出版信息
Phytomedicine. 2013 Feb 15;20(3-4):324-7. doi: 10.1016/j.phymed.2012.11.001.
BACKGROUND
Cutaneous squamous cell carcinoma (CSCC) is a common locally invasive skin cancer which rarely metastasises. First-line treatment is surgical excision, which is curative in most cases. Viscum album extract (VAE) is a widely used herbal cancer treatment with cytotoxic, apoptogenic and immunological effects, but has not been investigated in CSCC.
CASE PRESENTATION
A 78-year-old patient with histologically diagnosed CSCC refused surgical excision and was treated with peri-lesional high-dose VAE. After 10 months of treatment the CSCC had disappeared clinically. The patient has been recurrence-free for 4 years.
CONCLUSION
The presented case shows clinical response of a CSCC to high-dose peri-lesional VAE injections. Further research on VAE in CSCC is warranted.
背景
皮肤鳞状细胞癌（CSCC）是一种常见的局部侵袭性皮肤癌，很少发生转移。一线治疗是手术切除，大多数情况下是治愈性的。槲寄生提取物（VAE）是一种广泛应用于癌症治疗的草药，具有细胞毒性、促凋亡和免疫作用，但尚未在 CSCC 中进行研究。
病例介绍
一名 78 岁患者被组织学诊断为 CSCC，拒绝手术切除，接受了病变周围高剂量 VAE 治疗。治疗 10 个月后，CSCC 临床消失。患者至今已无复发 4 年。
结论
本病例显示 CSCC 对病变周围高剂量 VAE 注射有临床反应。进一步研究 VAE 在 CSCC 中的应用是必要的。
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