Sherid Muhammed, Sifuentes Humberto, Brasky Jeff, Shah Dhiren A, Ehrenpreis Eli D
Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA.
J Gastrointest Cancer. 2013 Mar;44(1):12-21. doi: 10.1007/s12029-012-9431-0.
Angiosarcoma of the gastrointestinal tract is an extremely rare tumor. We present two cases of angiosarcoma of the colon. One patient developed syncope and anemia and the other had rectal bleeding.
Endoscopic findings of the colon were different; the first case demonstrated a reddened colonic fold without an obvious mass and the other had an ulcerated friable mass. Both of the tumors had positive immunohistochemical stains for CD31 and CD34 (one was also positive for CD117). Surgery was not performed in either case. Treatment included chemotherapy with imatinib for the first patient and paclitaxel for the second. Prognosis for this tumor is generally poor; in our cases, one patient was still alive after 5 months of follow-up and the other died within 2 months of diagnosis. After presenting our cases, we reviewed the current literature on angiosarcoma of the colon.
胃肠道血管肉瘤是一种极其罕见的肿瘤。我们报告两例结肠血管肉瘤病例。一名患者出现晕厥和贫血，另一名患者有直肠出血。
结肠的内镜检查结果不同；第一例显示结肠皱襞发红，无明显肿块，另一例有溃疡易碎肿块。两种肿瘤的CD31和CD34免疫组化染色均为阳性（其中一例CD117也为阳性）。两例均未进行手术。治疗方面，第一例患者接受伊马替尼化疗，第二例接受紫杉醇化疗。该肿瘤的预后通常较差；在我们的病例中，一名患者在随访5个月后仍存活，另一名在诊断后2个月内死亡。在介绍我们的病例后，我们回顾了目前关于结肠血管肉瘤的文献。
