Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.
J Sleep Res. 2013 Aug;22(4):406-13. doi: 10.1111/jsr.12033. Epub 2013 Feb 11.
Studies suggest that the consolidation of newly acquired memories and underlying long-term synaptic plasticity might represent a major function of sleep. In a combined repeated-measures and parallel-group sleep laboratory study (active waking versus sleep, passive waking versus sleep), we provide evidence that brief periods of daytime sleep (42.1 ± 8.9 min of non-rapid eye movement sleep) in healthy adolescents (16 years old, all female), compared with equal periods of waking, promote the consolidation of declarative memory (word-pairs) in participants with high power in the electroencephalographic sleep spindle (sigma) frequency range. This observation supports the notion that sleep-specific brain activity when reaching a critical dose, beyond a mere reduction of interference, promotes synaptic plasticity in a hippocampal-neocortical network that underlies the consolidation of declarative memory.
研究表明，新获得的记忆的巩固和潜在的长期突触可塑性可能代表了睡眠的主要功能。在一项联合重复测量和并行组睡眠实验室研究（主动清醒与睡眠、被动清醒与睡眠）中，我们提供的证据表明，健康青少年（16 岁，均为女性）白天进行短暂的小睡（42.1±8.9 分钟的非快速眼动睡眠），与同等时间的清醒相比，促进了在脑电图睡眠纺锤波（西格玛）频率范围内具有高功率的参与者陈述性记忆（单词对）的巩固。这一观察结果支持了这样一种观点，即在达到临界剂量时，睡眠特有的大脑活动不仅仅是减少干扰，还促进了海马体-新皮层网络中的突触可塑性，而这种可塑性是陈述性记忆巩固的基础。
