Department of Geriatrics, Ghent University Hospital, Ghent, Belgium.
Eur J Clin Invest. 2013 Apr;43(4):379-86. doi: 10.1111/eci.12056. Epub 2013 Feb 10.
To assess and compare the predictive value of physical function measurements (PFMs) for all-cause mortality in older men and to evaluate the Timed Up and Go test (TUG) as a predictor in subjects with underlying comorbidity.
Observational study of a population-based sample of 352 ambulatory older men aged 71-86 at study baseline. The Rapid disability rating scale-2, 36-Item short form health survey, Grip strength, Five times sit-to-stand test, Standing balance, and TUG were determined at baseline. Associations with all-cause mortality were assessed using Cox proportional hazard analyses. Age, Body mass index (BMI), smoking status, education, physical activity and cognitive status were included as confounders. Follow-up exceeded 15 years. Comorbidity status was categorized into cardiovascular disease, chronic obstructive pulmonary disease (COPD) and diabetes mellitus.
All examined PFMs were associated with all-cause mortality. TUG was the best predictor (adjusted HR per SD increase = 1·58, 95% CI = 1·40-1·79, P < 0·001) for global mortality and continued to be predictive in subjects with cardiovascular disease (adjusted HR per SD increase = 1·80, 95% CI = 1·40-2·33, P < 0·001).
The assessment of physical functioning is important in the evaluation of older persons. We encourage the use of the TUG as a reliable, quick and feasible screening tool in clinical settings.
评估和比较体能测量（PFMs）对老年男性全因死亡率的预测价值，并评估在有潜在合并症的受试者中，计时起立行走测试（TUG）作为预测因子的能力。
对基础研究中有 352 名年龄在 71-86 岁的非卧床老年男性的基于人群的样本进行观察性研究。基线时确定了 Rapid disability rating scale-2、36-Item short form health survey、握力、五次坐立试验、站立平衡和 TUG。使用 Cox 比例风险分析评估与全因死亡率的相关性。年龄、体重指数（BMI）、吸烟状况、教育程度、身体活动和认知状况被纳入混杂因素。随访时间超过 15 年。合并症状况分为心血管疾病、慢性阻塞性肺疾病（COPD）和糖尿病。
所有检查的 PFMs 均与全因死亡率相关。TUG 是全因死亡率的最佳预测指标（SD 增加时的调整 HR = 1.58，95%CI = 1.40-1.79，P < 0.001），并且在心血管疾病患者中仍然具有预测能力（SD 增加时的调整 HR = 1.80，95%CI = 1.40-2.33，P < 0.001）。
体能评估在老年人评估中很重要。我们鼓励在临床环境中使用 TUG 作为可靠、快速和可行的筛查工具。
