Instituto Universitário de Lisboa (ISCTE-IUL), CIS-IUL, Lisbon, Portugal.
J Clin Exp Neuropsychol. 2013;35(3):269-78. doi: 10.1080/13803395.2013.770822. Epub 2013 Feb 11.
Age-related white matter changes have been associated with cognitive functioning, even though their role is not fully understood. This work aimed to test a 3-factor model of the neuropsychological assessment battery and evaluate how the model fit the data longitudinally. Confirmatory factor analysis (CFA) was used to investigate the dimensions of a structured set of neuropsychological tests administered to a multicenter, international sample of independent older adults (LADIS study). Six hundred and thirty-eight older adults completed baseline neuropsychological, clinical, functional and motor assessments, which were repeated each year for a 3-year follow-up. CFA provided support for a 3-factor model. These factors involve the dimensions of executive functions, memory functions, and speed and motor control abilities. Performance decreased in most neuropsychological measures. Results showed that executive functioning, memory and speed of motor abilities are valid latent variables of neuropsychological performance among older adults, and that this structure is relatively consistent longitudinally, even though performance decreases with time.
与认知功能相关的脑白质变化一直备受关注，尽管其作用尚未完全阐明。本研究旨在检验神经心理学评估工具的三因素模型，并评估该模型如何纵向拟合数据。采用验证性因子分析（CFA）对多中心、国际独立老年人（LADIS 研究）样本进行的一组结构性神经心理学测试的维度进行了研究。638 名老年人完成了基线神经心理学、临床、功能和运动评估，每 3 年进行一次为期 3 年的随访。CFA 支持三因素模型。这些因素涉及执行功能、记忆功能以及速度和运动控制能力等维度。大多数神经心理学测试的表现均下降。结果表明，在老年人中，执行功能、记忆和运动速度能力是神经心理学表现的有效潜在变量，并且即使随着时间的推移表现下降，该结构也具有相对一致性。
