合成具有小型病毒尺寸的大支化聚合物。
Synthesis of large dendrimers with the dimensions of small viruses.
机构信息
Department of Chemistry, Texas Christian University, Fort Worth, Texas 76129, USA.
出版信息
J Am Chem Soc. 2013 Mar 27;135(12):4660-3. doi: 10.1021/ja400432e. Epub 2013 Mar 13.
Abstract
The dendrimer chemistry reported offers a route to synthetic target molecules with spherical shape, well-defined surface chemistries, and dimensions that match the size of virus particles. The largest target, a generation-13 dendrimer comprising triazines linked by diamines, is stable across ranges of concentration, pH, temperature, solvent polarity and in the presence of additives. This dendrimer theoretically presents 16,384 surface groups and has a molecular weight exceeding 8.4 MDa. Transmission electron and atomic force microscopies, dynamic light scattering, and computations reveal a diameter of ~30 nm. The target was synthesized through an iterative divergent approach using a monochlorotriazine macromonomer providing two generations of growth per synthetic cycle. Fidelity in the synthesis is supported by evidence from NMR spectroscopy, mass spectrometry, and high-pressure liquid chromatography.
摘要
所报道的树状大分子化学提供了一种合成具有球形、明确表面化学性质和与病毒颗粒大小相匹配的尺寸的目标分子的途径。最大的目标是一种由通过二胺连接的三嗪组成的第一代 13 代树突状聚合物，在浓度、pH 值、温度、溶剂极性和添加剂存在的情况下均稳定。这种树突状聚合物理论上具有 16384 个表面基团，分子量超过 840 万道尔顿。透射电子显微镜和原子力显微镜、动态光散射和计算揭示了约 30nm 的直径。该目标是通过使用单氯三嗪大分子单体的迭代发散方法合成的，每轮合成提供两代生长。来自核磁共振波谱、质谱和高压液相色谱的证据支持了合成的保真度。
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