巴西一大型城市中不动杆菌脑膜炎的纵向监测。
Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil.
机构信息
Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
出版信息
Clin Microbiol Infect. 2013 May;19(5):E241-4. doi: 10.1111/1469-0691.12145. Epub 2013 Feb 11.
Abstract
The study aim was to describe the emergence of carbapenem resistance and clonal complexes (CC), defined by multilocus sequence typing (MLST), in Acinetobacter baumannii in a surveillance system for meningitis. Starting in 1996 in an urban setting of Brazil, surveillance detected meningitis by Acinetobacter sp for the first time in 2002. Up to 2008, 35 isolates were saved. Carbapenem resistance emerged in 2006, reaching 70% of A. baumannii isolates in 2008, including one that was colistin resistant. A. baumannii belonged to CC113/79 (University of Oxford/Institute Pasteur schemes), CC235/162 and CC103/15. Dissemination of infections resistant to all antimicrobial agents may occur in the future.
摘要
本研究旨在描述耐碳青霉烯类抗生素的鲍曼不动杆菌的出现以及克隆复合体（CC），该鲍曼不动杆菌是通过多位点序列分型（MLST）定义的，这是在脑膜炎监测系统中发现的。该监测系统始于 1996 年在巴西的一个城市环境中，于 2002 年首次检测到由不动杆菌引起的脑膜炎。截至 2008 年，共保存了 35 株分离株。2006 年出现耐碳青霉烯类抗生素的情况，到 2008 年，70%的鲍曼不动杆菌分离株对碳青霉烯类抗生素耐药，其中包括一株对黏菌素耐药的菌株。鲍曼不动杆菌属于 CC113/79（牛津大学/巴斯德研究所方案）、CC235/162 和 CC103/15。未来可能会出现对所有抗菌药物都耐药的感染传播。
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