对巴西碳青霉烯耐药鲍曼不动杆菌临床分离株的群体结构分析显示，克隆复合体1、15和79占主导地位。
Population Structure Analysis of Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates from Brazil Reveals Predominance of Clonal Complexes 1, 15, and 79.
作者信息
Camargo Carlos Henrique, Tiba Monique Ribeiro, Saes Marta Regina, Vasconcellos Francielli Mahnic de, Santos Luis Fernando Dos, Romero Eliete Caló, Garcia Doroti de Oliveira
机构信息
Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil
Centro de Bacteriologia, Instituto Adolfo Lutz, São Paulo, Brazil.
出版信息
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2545-7. doi: 10.1128/AAC.02186-15. Print 2016 Apr.
Abstract
The population structure of 71 carbapenem-resistantAcinetobacter baumanniiclinical isolates from several hospitals in Brazil was investigated by ApaI pulsed-field gel electrophoresis,blaOXA-51-like subtyping, and multilocus sequence typing (Institute Pasteur scheme). In addition to the predominance of strains carryingblaOXA-23, we detected the presence ofblaOXA-72andblaOXA-231 We observed a predominance of clonal complex 1 (CC1), CC15, and CC79 and representative strains of the worldwide-disseminated international clone I.
摘要
通过ApaI脉冲场凝胶电泳、blaOXA-51样亚型分析和多位点序列分型（巴斯德研究所方案），对来自巴西几家医院的71株耐碳青霉烯鲍曼不动杆菌临床分离株的群体结构进行了研究。除了携带blaOXA-23的菌株占优势外，我们还检测到blaOXA-72和blaOXA-231的存在。我们观察到克隆复合体1（CC1）、CC15和CC79以及全球传播的国际克隆I的代表性菌株占优势。
相似文献
1
Population Structure Analysis of Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates from Brazil Reveals Predominance of Clonal Complexes 1, 15, and 79.对巴西碳青霉烯耐药鲍曼不动杆菌临床分离株的群体结构分析显示，克隆复合体1、15和79占主导地位。
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2545-7. doi: 10.1128/AAC.02186-15. Print 2016 Apr.
2
Molecular Investigation of Carbapenem-Resistant Acinetobacter spp. from Hospitals in North Rhine-Westphalia, Germany.德国北莱茵-威斯特法伦州医院耐碳青霉烯类不动杆菌属的分子研究
Microb Drug Resist. 2017 Jan;23(1):25-31. doi: 10.1089/mdr.2016.0035. Epub 2016 Apr 19.
3
Distinct Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii from Colombian Hospitals.来自哥伦比亚医院的耐碳青霉烯鲍曼不动杆菌的独特遗传多样性。
Microb Drug Resist. 2018 Jan/Feb;24(1):48-54. doi: 10.1089/mdr.2016.0190. Epub 2017 Jun 1.
4
Transition of blaOXA-58-like to blaOXA-23-like in Acinetobacter baumannii Clinical Isolates in Southern China: An 8-Year Study.中国南方鲍曼不动杆菌临床分离株中blaOXA - 58样基因向blaOXA - 23样基因的转变：一项为期8年的研究
PLoS One. 2015 Sep 4;10(9):e0137174. doi: 10.1371/journal.pone.0137174. eCollection 2015.
5
OXA-Carbapenemases Present in Clinical Acinetobacter baumannii-calcoaceticus Complex Isolates from Patients in Kurdistan Region, Iraq.伊拉克库尔德地区患者临床分离的鲍曼不动杆菌-醋酸钙不动杆菌复合体菌株中存在的OXA-碳青霉烯酶
Microb Drug Resist. 2016 Dec;22(8):627-637. doi: 10.1089/mdr.2015.0060. Epub 2016 Mar 22.
6
A Multicenter Study in Mexico Finds Acinetobacter baumannii Clinical Isolates Belonging to Clonal Complexes 636B (113B) and 92B Harboring OXA-72, OXA-239, and OXA-469.墨西哥的一项多中心研究发现，属于克隆复合体636B（113B）和92B的鲍曼不动杆菌临床分离株携带OXA-72、OXA-239和OXA-469。
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2587-8. doi: 10.1128/AAC.02042-15. Print 2016 Apr.
7
Characterization of carbapenem-resistant Acinetobacter baumannii in Brazil (2008-2011): countrywide spread of OXA-23-producing clones (CC15 and CC79).巴西耐碳青霉烯鲍曼不动杆菌的特征（2008 - 2011年）：产OXA - 23克隆（CC15和CC79）在全国范围的传播。
Diagn Microbiol Infect Dis. 2014 Aug;79(4):468-72. doi: 10.1016/j.diagmicrobio.2014.03.006. Epub 2014 Mar 17.
8
The comparison of genotyping, antibiogram, and antimicrobial resistance genes between carbapenem-susceptible and -resistant Acinetobacter baumannii.碳青霉烯类敏感与耐药鲍曼不动杆菌之间的基因分型、抗菌谱及抗菌耐药基因比较
Comp Immunol Microbiol Infect Dis. 2014 Dec;37(5-6):339-46. doi: 10.1016/j.cimid.2014.10.002. Epub 2014 Oct 17.
9
Outbreak Caused by blaOXA-72-Producing Acinetobacter baumannii ST417 Detected in Clinical and Environmental Isolates.临床和环境分离株中检测到产blaOXA-72鲍曼不动杆菌ST417引起的暴发。
Microb Drug Resist. 2016 Mar;22(2):129-33. doi: 10.1089/mdr.2015.0157. Epub 2015 Aug 20.
10
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii in a Tertiary Care Hospital in Egypt: Clonal Spread of blaOXA-23.埃及一家三级护理医院耐碳青霉烯鲍曼不动杆菌的分子流行病学：blaOXA-23的克隆传播
Microb Drug Resist. 2018 Apr;24(3):269-277. doi: 10.1089/mdr.2017.0057. Epub 2017 Aug 7.
引用本文的文献
1
Phylogenomic analysis of aquatic and clinical OXA-23-positive belonging to the international clone 5 (ST79) from Southeast Brazil.对来自巴西东南部、属于国际克隆5（ST79）的水生和临床OXA - 23阳性菌株的系统基因组分析。
One Health. 2025 Jul 11;21:101140. doi: 10.1016/j.onehlt.2025.101140. eCollection 2025 Dec.
2
Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy.多黏菌素 B 联合治疗抑制鲍曼不动杆菌体外耐药性的药效学评价。
Sci Rep. 2021 May 31;11(1):11339. doi: 10.1038/s41598-021-90709-2.
3
Multidrug-resistant Acinetobacter baumannii outbreaks: a global problem in healthcare settings.多重耐药鲍曼不动杆菌爆发：医疗机构中的全球性问题。
Rev Soc Bras Med Trop. 2020 Nov 6;53:e20200248. doi: 10.1590/0037-8682-0248-2020. eCollection 2020.
4
Acinetobacter baumannii infections in Amazon Region driven by extensively drug resistant international clones, 2016-2018.2016-2018 年，亚马逊地区广泛耐药的国际克隆导致鲍曼不动杆菌感染。
Mem Inst Oswaldo Cruz. 2019 Nov 25;114:e190232. doi: 10.1590/0074-02760190232. eCollection 2019.
5
Emergence and Persistence of High-Risk Clones Among MDR and XDR at a Brazilian Teaching Hospital.巴西一家教学医院中耐多药和广泛耐药菌中高风险克隆株的出现与持续存在
Front Microbiol. 2019 Jan 4;9:2898. doi: 10.3389/fmicb.2018.02898. eCollection 2018.
6
Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru.秘鲁利马出现并传播碳青霉烯类耐药鲍曼不动杆菌国际克隆 II 和 III 型。
Emerg Microbes Infect. 2018 Jul 4;7(1):119. doi: 10.1038/s41426-018-0127-9.
7
Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii in the Intensive Care Unit of Uruguay's University Hospital Identifies the First rmtC Gene in the Species.乌拉圭大学医院重症监护病房耐碳青霉烯鲍曼不动杆菌的分子特征鉴定出该菌种中的首个rmtC基因。
Microb Drug Resist. 2018 Sep;24(7):1012-1019. doi: 10.1089/mdr.2017.0300. Epub 2018 Jun 19.
8
Distinct Genetic Diversity of Carbapenem-Resistant Acinetobacter baumannii from Colombian Hospitals.来自哥伦比亚医院的耐碳青霉烯鲍曼不动杆菌的独特遗传多样性。
Microb Drug Resist. 2018 Jan/Feb;24(1):48-54. doi: 10.1089/mdr.2016.0190. Epub 2017 Jun 1.
本文引用的文献
1
The changing epidemiology of Acinetobacter spp. producing OXA carbapenemases causing bloodstream infections in Brazil: a BrasNet report.巴西产OXA碳青霉烯酶不动杆菌属导致血流感染的流行病学变化：一份巴西网络报告
Diagn Microbiol Infect Dis. 2015 Dec;83(4):382-5. doi: 10.1016/j.diagmicrobio.2015.08.006. Epub 2015 Aug 12.
2
First report of NDM-1-producing Acinetobacter baumannii sequence type 25 in Brazil.巴西首次报告产NDM-1的鲍曼不动杆菌序列型25。
Antimicrob Agents Chemother. 2014 Dec;58(12):7592-4. doi: 10.1128/AAC.03444-14. Epub 2014 Oct 6.
3
OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain.OXA-207，一种来自西班牙皮氏不动杆菌的新型OXA-24变体，对碳青霉烯类药物的催化效率降低。
Antimicrob Agents Chemother. 2014 Aug;58(8):4944-8. doi: 10.1128/AAC.02633-13. Epub 2014 Jun 2.
4
Characterization of carbapenem-resistant Acinetobacter baumannii in Brazil (2008-2011): countrywide spread of OXA-23-producing clones (CC15 and CC79).巴西耐碳青霉烯鲍曼不动杆菌的特征（2008 - 2011年）：产OXA - 23克隆（CC15和CC79）在全国范围的传播。
Diagn Microbiol Infect Dis. 2014 Aug;79(4):468-72. doi: 10.1016/j.diagmicrobio.2014.03.006. Epub 2014 Mar 17.
5
Emergence of Acinetobacter baumannii international clone II in Brazil: reflection of a global expansion.巴西出现鲍曼不动杆菌国际克隆 II：全球扩张的反映。
Infect Genet Evol. 2013 Dec;20:378-80. doi: 10.1016/j.meegid.2013.09.028. Epub 2013 Oct 10.
6
Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil.巴西一大型城市中不动杆菌脑膜炎的纵向监测。
Clin Microbiol Infect. 2013 May;19(5):E241-4. doi: 10.1111/1469-0691.12145. Epub 2013 Feb 11.
7
Imported and intensive care unit-born Acinetobacter baumannii clonal complexes: one-year prospective cohort study in intensive care patients.进口和重症监护病房出生的鲍曼不动杆菌克隆复合体：重症监护患者一年前瞻性队列研究。
Microb Drug Resist. 2013 Jun;19(3):216-23. doi: 10.1089/mdr.2012.0174. Epub 2013 Jan 21.
8
Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages.全球多重耐药鲍曼不动杆菌克隆谱系的演变。
Int J Antimicrob Agents. 2013 Jan;41(1):11-9. doi: 10.1016/j.ijantimicag.2012.09.008. Epub 2012 Nov 3.
9
The challenges of antimicrobial resistance in Brazil.巴西的抗菌药物耐药性挑战。
Clin Infect Dis. 2011 May;52(9):1138-43. doi: 10.1093/cid/cir120.
10
Multiplex PCR for detection of acquired carbapenemase genes.多重 PCR 检测获得性碳青霉烯酶基因。
Diagn Microbiol Infect Dis. 2011 May;70(1):119-23. doi: 10.1016/j.diagmicrobio.2010.12.002. Epub 2011 Mar 12.
Zotero 插件