Caudill Laboratories, Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
Beilstein J Org Chem. 2013;9:166-72. doi: 10.3762/bjoc.9.19. Epub 2013 Jan 24.
A silyl glyoxylate three-component-coupling methodology has been exploited to achieve a formal synthesis, an analogue to an intermediate in a distinct formal synthetic route, and a third (unique) approach to the natural product alternaric acid. Highlighted in this study is the versatility of silyl glyoxylates to engage a variety of nucleophile and electrophile pairs to provide wide latitude in the approach to complex molecule synthesis.
利用硅基乙二醛三组分偶联方法实现了一种形式合成、独特形式合成途径中的一个中间体的类似物以及天然产物交替酸的第三种（独特的）方法。本研究的重点是硅基乙二醛的多功能性，它可以与各种亲核试剂和亲电试剂对结合，从而为复杂分子合成提供广泛的方法选择。
