Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Org Lett. 2011 Jun 17;13(12):3206-9. doi: 10.1021/ol2011192. Epub 2011 May 17.
A formal synthesis of leustroducsin B has been completed. The synthesis relies upon a recently developed Reformatsky/Claisen condensation of silyl glyoxylates and enantioenriched β-lactones that establishes two of the molecule's three core stereocenters and permits further elaboration to an intermediate in Imanishi's synthesis via reliable chemistry (Prasad reduction, asymmetric pentenylation, Mitsunobu inversion).
已完成利司扑兰 B 的全合成。该合成依赖于最近开发的硅基乙二醛酸酯和手性富集的β-内酰胺的 Reformatsky/Claisen 缩合反应，该反应建立了分子的三个核心手性中心中的两个，并通过可靠的化学方法（Prasad 还原、不对称戊烯化、Mitsunobu 反转）进一步衍生为 Imanishi 合成中的中间产物。
