Department of Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey.
J Clin Lab Anal. 2013 Mar;27(2):99-104. doi: 10.1002/jcla.21569. Epub 2013 Feb 11.
Ischemia-modified albumin (IMA) is a novel marker for diagnosis of myocardial ischemia and it is considered as a serum marker. The aim of the study was to evaluate salivary IMA levels in patients with acute myocardial infarction (AMI) and to determine the relation between serum and salivary IMA levels.
A total of 60 patients with AMI and 40 control subjects who are age and sex matched with AMI group were included in our study. The diagnosis of AMI was based on the WHO classification criteria. All patients underwent the clinical assessment, consisting of electrocardiography, and serum cardiac markers. Serum and salivary IMA levels were measured at the first and second days of AMI by using a colorimetric method.
Serum IMA levels were significantly higher in the first and second day of AMI patients, however, salivary IMA levels were significantly higher in the first day of AMI patients compared to the control (P < 0.05). There was a positive correlation between salivary IMA levels and serum IMA levels both in the first and second day of AMI patients (r = 0.298, P < 0.05; r = 0.319, P < 0.05, respectively).
We concluded that salivary IMA levels at the first day of AMI could be used as an alternative marker to serum IMA levels for diagnosis of AMI.
缺血修饰白蛋白（IMA）是一种用于诊断心肌缺血的新型标志物，被认为是一种血清标志物。本研究旨在评估急性心肌梗死（AMI）患者的唾液 IMA 水平，并确定血清和唾液 IMA 水平之间的关系。
本研究共纳入 60 例 AMI 患者和 40 例与 AMI 组年龄和性别匹配的对照组患者。AMI 的诊断基于世界卫生组织分类标准。所有患者均接受临床评估，包括心电图和血清心脏标志物检查。在 AMI 的第 1 天和第 2 天，使用比色法测量血清和唾液 IMA 水平。
AMI 患者第 1 天和第 2 天的血清 IMA 水平显著升高，而 AMI 患者第 1 天的唾液 IMA 水平显著高于对照组（P<0.05）。在 AMI 患者的第 1 天和第 2 天，唾液 IMA 水平与血清 IMA 水平之间均存在正相关（r=0.298，P<0.05；r=0.319，P<0.05）。
我们得出结论，AMI 第 1 天的唾液 IMA 水平可以作为血清 IMA 水平的替代标志物，用于诊断 AMI。
