General Dentistry, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, USA.
J Dent Res. 2010 Apr;89(4):389-94. doi: 10.1177/0022034509359884. Epub 2010 Feb 22.
Previous studies examined the serum immunoglobulin levels in relation to coronary artery disease (CAD). We hypothesized that the salivary immunoglobulins might better estimate oral infections in this relationship. Multivariate logistic regression analyses utilizing the data from 256 angiographically confirmed CAD patients and 250 non-CAD individuals that controlled for age, sex, smoking, diabetes, total/HDL cholesterol ratio, hypertension, and education revealed the trends that salivary IgA was positively and salivary IgG was inversely associated with CAD. The odds ratios (OR) of each increasing quartile of salivary IgA were 1.00 (first and second quartiles combined), 1.97, and 1.37 (p-value for trend = 0.06), while those for salivary IgG were 1.00, 0.77, 0.60, and 0.51 (p-value for trend = 0.02). Additionally, salivary IgA correlated positively with C-reactive protein and Asymptotic Dental Score (dental infection score), while IgG was inversely associated with these inflammation markers. Salivary IgA warrants further studies to confirm its role in the risk assessment of CAD.
先前的研究探讨了血清免疫球蛋白水平与冠状动脉疾病（CAD）之间的关系。我们假设唾液免疫球蛋白可能在这种关系中更好地估计口腔感染。利用 256 名经血管造影证实的 CAD 患者和 250 名非 CAD 个体的数据进行多变量逻辑回归分析，控制年龄、性别、吸烟、糖尿病、总胆固醇/高密度脂蛋白胆固醇比值、高血压和教育程度，结果表明唾液 IgA 呈正相关，而唾液 IgG 呈负相关与 CAD 相关。唾液 IgA 每个递增四分位的比值比（OR）分别为 1.00（第一和第二四分位数组合）、1.97 和 1.37（趋势检验 p 值=0.06），而唾液 IgG 的 OR 分别为 1.00、0.77、0.60 和 0.51（趋势检验 p 值=0.02）。此外，唾液 IgA 与 C 反应蛋白和渐近牙科评分（牙齿感染评分）呈正相关，而 IgG 与这些炎症标志物呈负相关。唾液 IgA 需要进一步研究以确认其在 CAD 风险评估中的作用。
