Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Clin Oral Investig. 2012 Jun;16(3):775-9. doi: 10.1007/s00784-011-0578-z. Epub 2011 Jun 18.
Myocardial infarction (MI) is the main cause of death all over the world. Biomarkers of cardiac necrosis are of great importance in the diagnosis of MI. The aim of this study was to determine probable changes of creatine kinase MB isoform (CK-MB) levels in saliva of patients with acute MI. A case-control study was carried out on 30 patients with acute MI who were hospitalized in Kamkar-Arabnia Hospital of Qom City and 30 healthy control subjects. CK-MB levels were measured by immunoinhibition assay in saliva and serum of patients and healthy individuals. Statistical analysis of the Student's t test and Pearson correlation coefficient was used. CK-MB levels showed a significant elevation in saliva and serum of patients with acute MI compared to healthy controls. Furthermore, there was a strong correlation between salivary levels of CK-MB and its serum values. Subsequent to an acute MI, there is a rise in salivary levels of CK-MB just as what occurs in the serum. Moreover, salivary levels of CK-MB reflect well its serum values. It seems that cardiac biomarker CK-MB is measurable in the saliva of patients with acute MI. Salivary CK-MB may serve as an easy-to-use diagnostic tool for point-of-care testing of acute MI.
心肌梗死（MI）是全世界死亡的主要原因。心肌坏死的生物标志物在 MI 的诊断中具有重要意义。本研究旨在确定急性 MI 患者唾液中肌酸激酶同工酶 MB 水平（CK-MB）的可能变化。对 Qom 市 Kamkar-Arabnia 医院住院的 30 名急性 MI 患者和 30 名健康对照者进行了病例对照研究。采用免疫抑制法测定患者和健康个体唾液和血清中的 CK-MB 水平。采用学生 t 检验和 Pearson 相关系数进行统计学分析。与健康对照组相比，急性 MI 患者的唾液和血清中 CK-MB 水平明显升高。此外，唾液 CK-MB 水平与血清值之间存在很强的相关性。急性 MI 后，CK-MB 的唾液水平像在血清中一样升高。此外，唾液 CK-MB 很好地反映了其血清值。似乎可以在急性 MI 患者的唾液中测量心脏生物标志物 CK-MB。唾液 CK-MB 可作为急性 MI 即时护理点检测的一种简便诊断工具。
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