Department of Otolaryngology, University Hospital Ostrava, 17 Listopadu 1790, 708 52 Ostrava, Czech Republic ; Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.
Gastroenterol Res Pract. 2013;2013:736486. doi: 10.1155/2013/736486. Epub 2013 Jan 17.
Objectives. To analyze the pH-monitoring records of patients with suspected extraesophageal reflux (EER) using three different parameters (number of refluxes (NOR), acid exposure time (AET), and reflux area index (RAI)), with a view to determining which type of analysis is best at selecting the patients who will respond to a proton pump inhibitor (PPI). Methods. Demographic data were obtained and the level of the complaint was assessed using the Visual Analogue Scale. A dual probe pH-monitoring study was conducted. NOR greater than six, AET more than 0.1%, and RAI higher than 6.3 mpH were taken to be the thresholds for EER. Subsequently the response to a 12-week PPI trial was analyzed. Results. A total of 81 patients were analyzed. The percentages of patients with substantial EER based on NOR, AET, and RAI were 36%, 28% and 26%, respectively. Statistically significant, often positive PPI trials were confirmed in the group identified as having substantial EER using all three types of analysis. When using AET and RAI, the significance was more pronounced (P = 0.012 and P = 0.013, resp.) in comparison with NOR (P = 0.033). Conclusions. Patients with EER diagnosed using AET or RAI will respond to PPI significantly often.
目的。使用三种不同参数（反流次数（NOR）、酸暴露时间（AET）和反流面积指数（RAI））分析疑似食管外反流（EER）患者的 pH 监测记录，以确定哪种分析类型最适合选择对质子泵抑制剂（PPI）有反应的患者。方法。获取人口统计学数据，并使用视觉模拟量表评估投诉水平。进行双探头 pH 监测研究。将 NOR 大于 6、AET 大于 0.1%和 RAI 大于 6.3 mpH 作为 EER 的阈值。随后分析对 12 周 PPI 试验的反应。结果。共分析了 81 名患者。基于 NOR、AET 和 RAI 的 EER 患者的百分比分别为 36%、28%和 26%。在使用所有三种类型的分析方法确定为存在实质性 EER 的组中，确认了具有统计学意义且常常呈阳性的 PPI 试验。与 NOR（P = 0.033）相比，当使用 AET 和 RAI 时，其显著性更为明显（P = 0.012 和 P = 0.013）。结论。使用 AET 或 RAI 诊断为 EER 的患者对 PPI 的反应非常频繁。
