Bar Ilan University.
Bar Ilan University; Department of Community Mental Health, University of Haifa, Israel.
Eur Psychiatry. 2014 Mar;29(3):149-52. doi: 10.1016/j.eurpsy.2012.11.006. Epub 2013 Feb 8.
This study aims to empirically identify age of onset groups and their clinical and background characteristics in forensic patients with schizophrenia. Hospital charts were reviewed of all 138 forensic patients with schizophrenia admitted to Geha Psychiatric Hospital that serves a catchment area of approximately 500,000 people, from 2000 to 2009 inclusive. Admixture analysis empirically identified early- (M=19.99, SD=3.31) and late-onset groups (M=36.13, SD=9.25). Early-onset was associated with more suicide attempts, violence before the age of 15, and early conduct problems, whereas late-onset was associated with a greater likelihood of violence after the age of 18 and marriage (P<0.01). The current findings provide clinicians with a unique direction for risk assessment and indicate differences in violence between early- and late-onset schizophrenia, particularly co-occurrence of harmful behavioral phenotypes.
本研究旨在通过实证分析确定精神分裂症法医患者的发病年龄组及其临床和背景特征。对 2000 年至 2009 年间,在服务约 50 万人的 Geha 精神病院收治的 138 名精神分裂症法医患者的住院病历进行了回顾。混合分析实证确定了早发(M=19.99,SD=3.31)和晚发组(M=36.13,SD=9.25)。早发与更多的自杀企图、15 岁前的暴力行为和早期品行问题有关,而晚发与 18 岁后发生暴力行为和结婚的可能性更大有关(P<0.01)。目前的研究结果为临床医生提供了风险评估的独特方向,并表明早发性和晚发性精神分裂症之间的暴力行为存在差异,特别是有害行为表型的共病。