Department of Biology, Tufts University, 200 Boston Ave. Suite 4700, Medford, MA 02155, USA.
FEBS Lett. 2013 Apr 17;587(8):1247-57. doi: 10.1016/j.febslet.2013.01.047. Epub 2013 Feb 10.
Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within proteins are modified on multiple amino acid sidechains by diverse enzymes to create a myriad of possible protein species. How these combinations of PTMs lead to distinct biological outcomes is only beginning to be understood. This manuscript highlights several examples of combinatorial PTMs in proteins, and describes recent technological developments, which are driving our ability to understand how PTM patterns may "code" for biological outcomes.
蛋白质会发生翻译后修饰（PTMs）。许多蛋白质中的结构域都可以被不同的酶在多个氨基酸侧链上进行修饰，从而产生无数可能的蛋白质种类。这些 PTM 组合如何导致不同的生物学结果，目前才刚刚开始被理解。本文主要介绍了蛋白质中几种组合 PTM 的例子，并描述了最近的技术发展，这些发展正在推动我们理解 PTM 模式如何“编码”生物学结果。
