Yang Chung S, Li Guangxun, Yang Zhihong, Guan Fei, Chen Amber, Ju Jihyeung
Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Department of Chemical Biology and Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, United States.
Cancer Lett. 2013 Jun 28;334(1):79-85. doi: 10.1016/j.canlet.2013.01.051. Epub 2013 Feb 8.
Tocopherols (vitamin E) and tea polyphenols have been reported to have cancer preventive activities. Large-scale human trials with high doses of alpha-tocopherol, however, have produced disappointing results. This review presents data showing that - and -tocopherols inhibit colon, lung, mammary and prostate carcinogenesis in animal models, whereas -tocopherol is ineffective in animal and human studies. Possible mechanisms of action are discussed. A broad cancer preventive activity of green tea polyphenols has been demonstrated in animal models, and many mechanisms have been proposed. The cancer preventive activity of green tea in humans, however, has not been conclusively demonstrated and remains to be further investigated.
生育酚（维生素E）和茶多酚据报道具有防癌活性。然而，高剂量α-生育酚的大规模人体试验产生了令人失望的结果。本综述展示的数据表明，γ-生育酚和δ-生育酚在动物模型中可抑制结肠癌、肺癌、乳腺癌和前列腺癌的发生，而α-生育酚在动物和人体研究中均无效。文中讨论了可能的作用机制。绿茶多酚在动物模型中已显示出广泛的防癌活性，并且已提出了许多作用机制。然而，绿茶对人类的防癌活性尚未得到确凿证实，仍有待进一步研究。
