Bioorganische Chemie, Gebäude NWI, Universität Bayreuth, 95440 Bayreuth, Germany.
Chem Soc Rev. 2013 May 21;42(10):4408-20. doi: 10.1039/c3cs35485g. Epub 2013 Feb 13.
Incremental developments in the chemistry of peptides, proteins and carbohydrates have enabled researchers to assemble entire glycoproteins with high precision. Based on sophisticated ligation chemistries pure glycoproteins bearing a single glycosylation pattern have become available. The impact of N-glycosylation on the function of glycoproteins is generally recognized but not well understood. Based on the recent advances in the synthesis of glycoproteins by chemical methods researchers can finally start to elucidate the various roles of carbohydrates in complex biomolecules in detail.
多肽、蛋白质和碳水化合物化学的不断发展使研究人员能够高精度地组装整个糖蛋白。基于复杂的连接化学，具有单一糖基化模式的纯糖蛋白已经可以获得。N-糖基化对糖蛋白功能的影响已得到普遍认可，但认识并不深入。基于化学方法合成糖蛋白的最新进展，研究人员终于可以开始详细阐明碳水化合物在复杂生物分子中的各种作用。
