Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea.
Integr Biol (Camb). 2013 Apr;5(4):669-72. doi: 10.1039/c3ib20203h. Epub 2013 Feb 13.
We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to CD44-expressing stem-like gastric cancer cells. Furthermore, NIR-sensitive in vivo imaging potentials of CD44-targetable NIRSHs for heterotopic/orthotopic xenograft mouse models were investigated.
我们描述了一种基于水凝胶复合物的近红外敏感分子成像探针，该探针可以靶向一种类干细胞胃癌细胞标志物（CD44，一种常与患者预后不良相关的标志物）。因此，通过在水相中介导聚集体形成，制备了靶向 CD44 和近红外敏感的超分子水凝胶（NIRSH，Cy5.5 标记的聚乙烯亚胺/透明质酸聚集体）。NIRSH 表现出良好的水稳定性、生物相容性和对表达 CD44 的类干细胞胃癌细胞的特异性。此外，还研究了靶向 CD44 的 NIRSH 的近红外敏感体内成像潜力，用于异位/原位异种移植小鼠模型。
