Lin ShuChen, Xu YingChun, Gan ZhiHua, Han Kun, Hu HaiYan, Yao Yang, Huang MingZhu, Min DaLiu
Department of Oncology, Shanghai Sixth People's Hospital East Campus, Shanghai Jiao Tong University, People's Republic of China.
Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, People's Republic of China.
Onco Targets Ther. 2016 Feb 11;9:731-40. doi: 10.2147/OTT.S96645. eCollection 2016.
Cancer stem cells (CSCs) are a small, characteristically distinctive subset of tumor cells responsible for tumor initiation and progression. Several treatment modalities, such as surgery, glycolytic inhibition, driving CSC proliferation, immunotherapy, and hypofractionated radiotherapy, may have the potential to eradicate CSCs. We propose that monitoring CSCs is important in clinical oncology as CSC populations may reflect true treatment response and assist with managing treatment strategies, such as defining optimal chemotherapy cycles, permitting pretreatment cancer surveillance, conducting a comprehensive treatment plan, modifying radiation treatment, and deploying rechallenge chemotherapy. Then, we describe methods for monitoring CSCs.
癌症干细胞（CSCs）是一小群具有独特特征的肿瘤细胞亚群，负责肿瘤的起始和进展。几种治疗方式，如手术、糖酵解抑制、驱动CSC增殖、免疫疗法和大分割放疗，可能有根除CSCs的潜力。我们提出，监测CSCs在临床肿瘤学中很重要，因为CSC群体可能反映真正的治疗反应，并有助于管理治疗策略，如确定最佳化疗周期、进行治疗前癌症监测、制定综合治疗计划、调整放射治疗以及采用再挑战化疗。然后，我们描述了监测CSCs的方法。
