Nakasone Yasushi, Nakamura Yosuke, Yamamoto Tetsuro, Yamaguchi Hideyo
Kenkoukazoku, Inc., Kagoshima 892-0848;
Exp Ther Med. 2013 Feb;5(2):399-405. doi: 10.3892/etm.2012.819. Epub 2012 Nov 20.
Numerous clinical studies have used differing garlic preparations leading to controversial results with regard to the hypotensive effect of garlic. This randomized, double-blind, placebo-controlled study was designed to determine the effect of a traditional Japanese garlic homogenate-based supplementary diet (GH diet) product on blood pressure (BP) in subjects with prehypertension and in those with mild hypertension. In total, 34 eligible subjects with prehypertension and 47 with mild hypertension were treated with a daily dose of GH diet (300 mg as dried garlic homogenate; n=16 and 23, respectively) or placebo (n=18 and 24, respectively) for 12 weeks. Of these, 32 prehypertensive subjects (15 on the GH diet and 17 on the placebo) and 40 mildly hypertensive subjects (19 on the GH diet and 21 on the placebo) completed the study and were subjected to efficacy analyses. Systolic and diastolic BPs were monitored at weeks 4, 8 and 12 during the treatment and at post-week 4 following the termination of the treatment. The GH diet induced significant reductions of systolic BP (of between 6.6 and 7.5 mmHg) and diastolic BP (of between 4.6 and 5.2 mmHg) compared with the placebo subsequent to 8 and 12 weeks of treatment. A 12-week intake of the GH diet did not cause any clinically problematic side-effects. We conclude that the GH diet was well tolerated, and had a clinically relevant hypotensive effect in adults with mild hypertension, but not in those with prehypertension.
众多临床研究使用了不同的大蒜制剂，导致关于大蒜降压效果的结果存在争议。这项随机、双盲、安慰剂对照研究旨在确定一种基于传统日本大蒜匀浆的补充饮食（GH饮食）产品对高血压前期和轻度高血压患者血压的影响。总共34名符合条件的高血压前期患者和47名轻度高血压患者每天服用GH饮食（300毫克干大蒜匀浆；分别为n = 16和23）或安慰剂（分别为n = 18和24），持续12周。其中，32名高血压前期患者（15名服用GH饮食，17名服用安慰剂）和40名轻度高血压患者（19名服用GH饮食，21名服用安慰剂）完成了研究并接受疗效分析。在治疗期间的第4、8和12周以及治疗结束后的第4周后监测收缩压和舒张压。与安慰剂相比，治疗8周和12周后，GH饮食使收缩压显著降低（6.6至7.5毫米汞柱），舒张压显著降低（4.6至5.2毫米汞柱）。摄入12周的GH饮食未引起任何临床问题的副作用。我们得出结论，GH饮食耐受性良好，对轻度高血压成年人有临床相关的降压作用，但对高血压前期患者没有。
