Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute of Aging, Baltimore, Maryland, USA.
Obesity (Silver Spring). 2013 Jan;21(1):E10-3. doi: 10.1002/oby.20010.
Being overweight or obese increases the risk of elevated blood pressure. However differences of their effects on blood pressure in different age groups are not clear.
The aim of the present study was to evaluate differences of the effects of adiposity on the odds of having hypertension in different age groups.
Three thousand fifty-six subjects (1,532 women and 1,524 men) consist of the drug naïve subjects from the SardiNIA study. Logistic regression models with backward elimination were used to determine and compare the association between categories of obesity on hypertension within young (≤ 39), middle aged (40-59), and older (60+) subjects. Additional terms controlled for in the model were smoking and alcohol intake status.
The relationship of body mass index (BMI) on hypertension differed by age, as indicated by the significant interaction term of age with BMI (P <0.01). Older subjects had higher odds of having hypertension than younger subjects but these odds were lower for obese than for lean subjects (OR 10.45, 95% CIs 4.58-23.85 in obese versus OR 33.89, 95% CIs 17.94-64.02 in lean subjects). A similar trend was also observed in middle aged subjects.
This study shows that among men and women, older age was associated with a lesser effect of BMI on the odds of having hypertension.
超重或肥胖会增加血压升高的风险。然而，不同年龄组中它们对血压的影响差异尚不清楚。
本研究旨在评估肥胖对不同年龄组高血压患病风险的影响差异。
本研究纳入了来自 SardiNIA 研究的 3056 名（1532 名女性和 1524 名男性）未经药物治疗的受试者。采用向后消除的逻辑回归模型来确定和比较肥胖类别与年轻（≤39 岁）、中年（40-59 岁）和老年（60 岁以上）受试者中高血压之间的关联。模型中还控制了吸烟和饮酒状况等其他因素。
体重指数（BMI）与高血压的关系因年龄而异，年龄与 BMI 的交互项具有统计学意义（P<0.01）。与年轻受试者相比，老年受试者发生高血压的几率更高，但肥胖受试者的几率低于消瘦受试者（肥胖者的比值比为 10.45，95%置信区间为 4.58-23.85；消瘦者的比值比为 33.89，95%置信区间为 17.94-64.02）。这一趋势在中年受试者中也观察到。
本研究表明，在男性和女性中，随着年龄的增长，BMI 对高血压患病风险的影响会减弱。
