Murata Y, Miyamoto E, Ueda M
School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Caries Res. 1990;24(2):113-6. doi: 10.1159/000261250.
Some antimicrobial compounds were tested for their antiplaque activity by a simple method involving measurement of the weight of Streptococcus sobrinus plaque on a glass surface. Chlorhexidine, cetylpyridinium chloride, and n-tetradecylamine reduced the weight of plaque produced by S. sobrinus in vitro; some N-palmityl and palmitoyl derivatives of polymethylenediamines were also found to possess antiplaque activity. The results suggest that an antiplaque effect does not necessarily depend on high bactericidal activity.
通过一种简单的方法对一些抗菌化合物的抗牙菌斑活性进行了测试，该方法包括测量玻璃表面变形链球菌菌斑的重量。洗必泰、氯化十六烷基吡啶和正十四烷基胺在体外可减轻变形链球菌产生的菌斑重量；还发现一些聚亚甲基二胺的N-棕榈酰和棕榈酰衍生物具有抗牙菌斑活性。结果表明，抗牙菌斑作用不一定取决于高杀菌活性。
