Dem Ahmadou, Dieng Mamadou Moustapha, Ka Sidy, Gaye Pape Macoumba, Diouf Doudou, Gaye-Fall Mame Coumba
Université Cheikh Anta Diop de Dakar-Sénégal, Institut du Cancer, 6604 Dakar-Étoile, Sénégal.
Bull Cancer. 2013 Feb 1;100(2):155-60. doi: 10.1684/bdc.2013.1693.
Epithelial ovarian cancer are the most frequent of ovarian cancer, their prognosis is very bad. The aim of this study is to describe the diagnosis, the treatment and to assess the survival rate of the patients.
It was a retrospective study realized at the Cancer Institute of Dakar from December 2000 to January 2007. We have collected 117 patients with epithelial ovarian cancer. The mean age was 49 years. Patients were comprised: 22 stage I, 32 stage II, 35 stage III and 26 stage IV. Primary surgery was performed to 34 patients and the other patients were treated with chemotherapy and surgery. The survival rate was assessed by Kaplan-Meier method and the Logrank test had allowed to compare the survival among age and optimal surgery.
Optimal surgery R0 was done in 20 cases and surgical resection R2 was performed in 45 cases. Pathological exam had found 65 serous cystadenocarcinoma, 28 mucinous cystadenocarcinoma and 21 endometrioid cystadenocarcinoma, one malignant tumor of Brenner. Overall survival at five years was 13.3%. The survival among optimal surgery was 16.3 and 2.3% for suboptimal surgery. There was no significant difference of the survival among patients who were less than 40 years old (P = 0.334).
Prognosis of epithelial ovarian cancer is worse in Senegal as like as in the world. To improve the survival of our patients, we must detect the early diagnosis of these tumors and to introduce the neoadjuvant chemotherapy before optimal surgery.
上皮性卵巢癌是最常见的卵巢癌类型，其预后很差。本研究的目的是描述上皮性卵巢癌的诊断、治疗并评估患者的生存率。
这是一项于2000年12月至2007年1月在达喀尔癌症研究所开展的回顾性研究。我们收集了117例上皮性卵巢癌患者。平均年龄为49岁。患者包括：22例I期、32例II期、35例III期和26例IV期。34例患者接受了初次手术，其他患者接受了化疗和手术。采用Kaplan-Meier方法评估生存率，Logrank检验用于比较年龄和最佳手术情况下的生存率。
20例患者完成了R0最佳手术，45例患者进行了R2手术切除。病理检查发现65例浆液性囊腺癌、28例黏液性囊腺癌、21例子宫内膜样囊腺癌和1例勃勒纳氏瘤恶性肿瘤。五年总生存率为13.3%。最佳手术患者的生存率为16.3%，次优手术患者的生存率为2.3%。年龄小于40岁的患者之间生存率无显著差异（P = 0.334）。
与世界其他地区一样，塞内加尔上皮性卵巢癌的预后较差。为提高我们患者的生存率，我们必须早期诊断这些肿瘤，并在最佳手术前引入新辅助化疗。
