Behtash N, Modares M, Abolhasani M, Ghaemmaghami F, Mousavi M, Yarandi F, Hanjani P
Department of Gynecology and Oncology, Tehran University of Medical Sciences, Tehran, Iran.
J Obstet Gynaecol. 2004 Feb;24(2):157-60. doi: 10.1080/01443610310001645460.
Thirty-eight patients with ovarian tumours of low malignant potential (borderline) were diagnosed and treated in Tehran University Gynecology Oncology Department from 1991 to 2002, and have been reviewed. In this study age, clinical behavior, symptoms, surgical stage, type of tumour, surgery, adjuvant treatment, survival and recurrences were evaluated. A retrospective chart review was performed on these 38 patients who were treated for histopathologically confirmed tumours of low malignant potential between 1991-2002. The mean age was 34.4 years, range (14-83) (SD: 18.33). Post surgical FIGO staging was: Stage I=93.75%, stage III 6.25%. Histologic subtypes were: Serous 76.31% (29 patients), Mucinous 21.05% (8 patients), Mixed types 2.63% (1 patient). Mean pre-operative CA125 value was 114.90 (SD: +/- 90.30). Thirty-three percent of patients had only a simple cyst in ultrasonography. Conservative surgery was performed in 76.32% (29 patients). More radical surgery (TAH + BSO) was performed in 9 patients (23.68%). There were 6 recurrences. Three patients with recurrence and invasive implants received chemotherapy and secondary surgery was performed. Survival rate was 100% at 3 years for all stages and 89% at 5 years. One patient died of recurrent disease at 48 months after initial diagnosis. Our data suggest that LMP tumours are most frequently diagnosed in stage I. Most common histological type was serous, and 5 of the recurrences of (6 patients) were initially diagnosed at stage I, and had been treated with conservative surgery with no adjuvant therapy.
1991年至2002年期间，德黑兰大学妇科肿瘤学系诊断并治疗了38例低恶性潜能（交界性）卵巢肿瘤患者，并进行了回顾性研究。本研究对年龄、临床行为、症状、手术分期、肿瘤类型、手术方式、辅助治疗、生存情况和复发情况进行了评估。对这38例在1991年至2002年间接受组织病理学确诊为低恶性潜能肿瘤治疗的患者进行了回顾性病历审查。平均年龄为34.4岁，范围（14 - 83岁）（标准差：18.33）。术后国际妇产科联盟（FIGO）分期为：I期 = 93.75%，III期 = 6.25%。组织学亚型为：浆液性76.31%（29例患者），黏液性21.05%（8例患者），混合型2.63%（1例患者）。术前CA125平均 值为114.90（标准差：±90.30）。33%的患者超声检查仅发现单纯囊肿。76.32%（29例患者）进行了保守手术。9例患者（23.68%）进行了更根治性的手术（全子宫切除 + 双侧附件切除）。有6例复发。3例复发且有浸润性种植转移的患者接受了化疗并进行了二次手术。所有分期的3年生存率为100%，5年生存率为89%。1例患者在初次诊断后48个月死于复发性疾病。我们的数据表明，低恶性潜能肿瘤最常诊断为I期。最常见的组织学类型是浆液性，6例复发患者中有5例最初诊断为I期，且接受了保守手术，未进行辅助治疗。
