Daijikai Mihara Hospital, Mihara, Japan.
Neuropsychobiology. 2013;67(2):103-10. doi: 10.1159/000345161. Epub 2013 Feb 9.
Only a few studies have examined the relationships between affective symptoms, cognitive function (e.g. verbal fluency), quality of life (QOL), and brain activation in a nonclinical population. The aim of the present study was to assess these relationships and examine the underlying cortical mechanisms in a nonclinical population. Fifty-two healthy male volunteers were assessed for depressive symptoms using the Zung Self-Rating Depression Scale (SDS), for apathy using the Apathy Scale, and QOL using the Medical Outcomes Study short-form 36-item questionnaire (SF36). The volunteers also performed a verbal fluency test (VFT) while hemoglobin concentration changes were assessed on the surface of the frontal cortex using 24-channel near-infrared spectroscopy (NIRS). The SDS and Apathy Scale scores showed significant negative correlations with the scores of most of the SF36 subscales. Frontal activation had a significant negative correlation with the SDS scores and the Apathy Scale. These results suggest that the degree of affective symptoms is associated with a lower QOL in a nonclinical population, and that cortical hypoactivation during a VFT measured by NIRS may objectively identify individuals with a high degree of affective symptoms.
仅有少数研究考察了非临床人群中情感症状、认知功能（如言语流畅性）、生活质量（QOL）和大脑激活之间的关系。本研究旨在评估这些关系，并研究非临床人群中的潜在皮质机制。52 名健康男性志愿者使用zung 自评抑郁量表（SDS）评估抑郁症状，使用淡漠量表评估淡漠症状，使用医疗结局研究 36 项简短量表（SF36）评估生活质量。志愿者还进行了言语流畅性测试（VFT），同时使用 24 通道近红外光谱（NIRS）评估额叶皮质表面的血红蛋白浓度变化。SDS 和淡漠量表评分与 SF36 大多数子量表的评分呈显著负相关。额叶激活与 SDS 评分和淡漠量表呈显著负相关。这些结果表明，在非临床人群中，情感症状的严重程度与生活质量较低有关，并且 NIRS 测量的 VFT 期间皮质低激活可能客观地识别出具有高度情感症状的个体。
