比较氯己定局部应用与传统脐带干燥护理对新生儿败血症风险的影响：一项随机对照试验。
Effect of topical application of chlorhexidine for umbilical cord care in comparison with conventional dry cord care on the risk of neonatal sepsis: a randomized controlled trial.
机构信息
Department of Pediatrics, Pandit B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana 124001, India.
出版信息
J Trop Pediatr. 2013 Jun;59(3):209-13. doi: 10.1093/tropej/fmt003. Epub 2013 Feb 13.
AIM
To compare topical application of chlorhexidine for umbilical cord care with conventional dry care for prevention of neonatal sepsis in neonatal intensive care unit (NICU).
METHODS
The study was conducted in the NICU of a teaching hospital in north India between 2010 and 2011. Newborns (≥ 32 weeks of gestation and weighing ≥ 1500 g) were randomized into chlorhexidine application and dry care groups. Data regarding time of cord separation, umbilical sepsis and neonatal sepsis were recorded.
RESULTS
One hundred forty (dry care group 70, chlorhexidine group 70) were enrolled and finally analysed. A significant difference was observed among groups in terms of time to cord separation and incidence of blood culture-proven sepsis though there was no statistical difference noted among the groups with regards to umbilical infection, probable sepsis and meningitis.
CONCLUSION
Use of chlorhexidine for umbilical cord care prevents sepsis in the NICU.
目的
比较聚维酮碘局部应用于脐带护理与传统的干燥护理在新生儿重症监护病房（NICU）预防新生儿败血症的效果。
方法
该研究于 2010 年至 2011 年在印度北部一家教学医院的 NICU 进行。将（胎龄≥32 周且体重≥1500g）的新生儿随机分为聚维酮碘组和干燥护理组。记录脐带分离时间、脐炎和新生儿败血症的数据。
结果
共纳入 140 例（干燥护理组 70 例，聚维酮碘组 70 例），最终进行了分析。尽管在脐带感染、疑似败血症和脑膜炎方面，两组之间没有统计学差异，但在脐带分离时间和血培养证实的败血症发生率方面，两组之间存在显著差异。
结论
在 NICU 中使用聚维酮碘进行脐带护理可预防败血症。
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