Smales O
Memorial-Hospital, Hastings.
N Z Med J. 1988 Jul 13;101(849):453-5.
Owing to a high incidence of superficial infection in the newborn period the existing cord care treatment of Iodosan 10% in surgical spirit was compared with 4% chlorhexidine detergent solution. A prospective crossover study was performed between two comparable maternity units. Cord bacteriology was assessed at the time of discharge from hospital and the day of cord separation recorded. The number of infections involving skin, eyes and umbilical cord occurring in hospital and at home were recorded. Chlorhexidine treatment of the cord was associated with an overall reduction in bacterial colonisation of the cord. This was most marked for coagulase positive staphylococci and was not associated with an increase in gram negative organisms. Cord separation occurred at a mean of 10 days with Iodosan and 20 days with chlorhexidine. Chlorhexidine treatment was associated with fewer infections overall; 21% of babies v 38% of babies treated with Iodosan. Conjunctival infection was most commonly recorded; 48 babies being affected in the Iodosan group and 20 in the chlorhexidine group. The use of 4% chlorhexidine detergent solution is supported, but the length of treatment may have to be limited in order to encourage cord separation.
由于新生儿期浅表感染的发生率较高，将现有的10%碘附（Iodosan）乙醇溶液脐带护理治疗方法与4%氯己定洗涤剂溶液进行了比较。在两个类似的产科病房进行了一项前瞻性交叉研究。在出院时评估脐带细菌学情况，并记录脐带脱落的日期。记录在医院和家中发生的涉及皮肤、眼睛和脐带的感染数量。氯己定处理脐带与脐带细菌定植的总体减少有关。这在凝固酶阳性葡萄球菌中最为明显，且与革兰氏阴性菌的增加无关。使用碘附时脐带平均在10天脱落，使用氯己定时则为20天。氯己定治疗总体上感染较少；使用碘附治疗的婴儿中有21%发生感染，而使用氯己定治疗的婴儿中有38%发生感染。结膜感染记录最为常见；碘附组有48名婴儿受影响，氯己定组有20名婴儿受影响。支持使用4%氯己定洗涤剂溶液，但可能必须限制治疗时间以促进脐带脱落。
