Lin Guangzhu, Yu Xiaofeng, Wang Jing, Qu Shaochun, Sui Dayuan
Department of Pharmacology, School of Pharmacy; China-Japan Union Hospital, Jilin University, Changchun 130021, P.R. China ; Department of Cardiovascular Medicine, First Hospital; China-Japan Union Hospital, Jilin University, Changchun 130021, P.R. China.
Exp Ther Med. 2013 Feb;5(2):443-447. doi: 10.3892/etm.2012.820. Epub 2012 Nov 20.
20(S)-protopanaxadiol (PPD) is an extract of Panax quinquefolius L. The aim of this study was to investigate the effect of PPD on the antitumor activity and toxicity of cyclophosphamide (CTX) in tumor-bearing mice. C57BL/6 mice bearing Lewis lung carcinoma cells were treated with PPD (50 mg/kg) alone, CTX (20 mg/kg) alone or PPD (50 mg/kg) in combination with CTX (20 mg/kg), respectively. The results showed that PPD alone has no significant antitumor activity but synergistically enhanced the antitumor activity of CTX. PPD significantly increased the peripheral white blood cell count, bone marrow cell count, interleukin-2 and interferon-γ in CTX-treated tumor-bearing mice. The lowered levels of spleen index, splenocyte proliferation and natural killer cell activity in tumor-bearing mice following CTX treatment were also increased by PPD administration. PPD may be a beneficial supplement during CTX chemotherapy for enhancing the antitumor efficacy and reducing the toxicity of CTX.
20(S)-原人参二醇（PPD）是西洋参的提取物。本研究旨在探讨PPD对荷瘤小鼠环磷酰胺（CTX）抗肿瘤活性及毒性的影响。将接种Lewis肺癌细胞的C57BL/6小鼠分别单独给予PPD（50mg/kg）、单独给予CTX（20mg/kg）或PPD（50mg/kg）与CTX（20mg/kg）联合用药。结果表明，单独使用PPD无明显抗肿瘤活性，但能协同增强CTX的抗肿瘤活性。PPD显著提高了CTX治疗的荷瘤小鼠外周血白细胞计数、骨髓细胞计数、白细胞介素-2和干扰素-γ水平。PPD给药还提高了CTX治疗后荷瘤小鼠降低的脾脏指数、脾细胞增殖和自然杀伤细胞活性。PPD可能是CTX化疗期间有益的补充剂，可增强抗肿瘤疗效并降低CTX的毒性。
