Meyne J, Baker R J, Hobart H H, Hsu T C, Ryder O A, Ward O G, Wiley J E, Wurster-Hill D H, Yates T L, Moyzis R K
Genetics Group, Los Alamos National Laboratory, NM 87545.
Chromosoma. 1990 Apr;99(1):3-10. doi: 10.1007/BF01737283.
The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.
我们测定了100种脊椎动物物种中（TTAGGG）n端粒重复序列的非端粒位点在染色体内部的分布情况。该序列最常见的非端粒位置位于染色体的着丝粒周围区域。多种物种在组成型异染色质区域内显示出相对大量的该序列。我们讨论了（TTAGGG）n序列的非端粒分布与核型进化过程之间可能的关系，在此过程中这些位点可能提供潜在的新端粒。
