Chen Shaomin, Guo Lijun, Chen Baoxia, Sun Lijie, Cui Ming
Department of Cardiology, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing 100191, P.R. China.
Exp Ther Med. 2013 Mar;5(3):937-941. doi: 10.3892/etm.2013.893. Epub 2013 Jan 14.
The aim of the present study was to investigate the association of the serum angiopoietin (Ang)-1 and Ang-2 levels and the Ang-2 to Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients with acute myocardial infarction (AMI) during hospitalization. The serum Ang-1 and Ang-2 levels of the AMI patients were measured at admission to hospital. The correlations between serum Ang-1, Ang-2 and Ang-2/Ang-1 with HF were examined. Among 103 patients, 20 developed HF during hospitalization. The serum Ang-2 level and Ang-2/Ang-1 were found to be significantly higher in the patients with HF than in the patients without HF (2,203.1±122.0 vs. 2,102.3±114.4 pg/ml, P=0.001 and 11.4±1.6×10(-2) vs. 10.6±1.1×10(-2), P=0.007, respectively). Serum Ang-2 level and Ang-2/Ang-1 were negatively correlated with left ventricular ejection fraction (LVEF; r=-0.352, P<0.001 and r=-0.365, P<0.001, respectively) and positively correlated with the natural logarithm of the level of N-terminal pro-B-type natriuretic peptide (LnNT-proBNP, r=0.367, P<0.001 and r=0.304, P=0.003, respectively) and peak cardiac troponin T (cTnT, r=0.421, P<0.001 and r=0.278, P=0.009, respectively). However, the serum Ang-1 level was not found to correlate significantly with LVEF (r= 0.194, P= 0.05), LnNT-proBNP (r=-0.116, P=0.266) or peak cTnT (r=-0.056, P=0.607). In multivariable logistic regression analysis, Ang-2 (P=0.031), Ang-2/Ang-1 (P=0.018) and NT-proBNP (P=0.001) were revealed to be independently associated with HF. The present study reveals that Ang-2 levels and Ang-2/Ang-1 are independent predictors of HF in AMI patients during hospitalization.
本研究旨在探讨急性心肌梗死（AMI）患者住院期间血清血管生成素（Ang）-1和Ang-2水平以及Ang-2与Ang-1的比值（Ang-2/Ang-1）与心力衰竭（HF）的相关性。在入院时测定AMI患者的血清Ang-1和Ang-2水平。检测血清Ang-1、Ang-2和Ang-2/Ang-1与HF之间的相关性。103例患者中，20例在住院期间发生HF。发现HF患者的血清Ang-2水平和Ang-2/Ang-1显著高于无HF患者（分别为2203.1±122.0 vs. 2102.3±114.4 pg/ml，P=0.001；11.4±1.6×10⁻² vs. 10.6±1.1×10⁻²，P=0.007）。血清Ang-2水平和Ang-2/Ang-1与左心室射血分数（LVEF）呈负相关（r=-0.352，P<0.001；r=-0.365，P<0.001），与N末端B型利钠肽原水平的自然对数（LnNT-proBNP，r=0.367，P<0.001；r=0.304，P=0.003）以及心肌肌钙蛋白T峰值（cTnT，r=0.421，P<0.001；r=0.278，P=0.009）呈正相关。然而，未发现血清Ang-1水平与LVEF（r=0.194，P=0.05）、LnNT-proBNP（r=-0.116，P=0.266）或cTnT峰值（r=-0.056，P=0.607）有显著相关性。在多变量逻辑回归分析中，Ang-2（P=0.031）、Ang-2/Ang-1（P=0.018）和NT-proBNP（P=0.001）被发现与HF独立相关。本研究表明，Ang-2水平和Ang-2/Ang-1是AMI患者住院期间HF的独立预测因子。
