Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China.
NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China.
Braz J Cardiovasc Surg. 2023 Feb 10;38(1):104-109. doi: 10.21470/1678-9741-2021-0364.
There are few circulating biomarkers for valvular heart disease. Angiopoietin (Ang) 1, Ang2, and vascular endothelial growth factor are important inflammation-associated cytokines. The aim of this study was to investigate the clinical significance and association of Ang1, Ang2, and vascular endothelial growth factor in valvular heart disease.
This is a retrospective study; a total of 62 individuals (valvular heart disease patients [n=42] and healthy controls [n=20]) were included. Plasma levels of Ang1, Ang2, and vascular endothelial growth factor were detected by enzyme-linked immunosorbent assays. We retrospectively collected the baseline characteristics and short-term outcomes; logistic regression was performed to identify predictor for short-term mortality.
Ang2 was significantly decreased in the valvular heart disease group compared with the healthy control group (P=0.023), while no significant difference was observed in the Ang1 and vascular endothelial growth factor levels. The Ang2 level of New York Heart Association (NYHA) I/II patients - but not NYHA III/IV patients - was significantly decreased compared with that of healthy control individuals (NYHA I/II: P=0.017; NYHA III/IV: P=0.485). Univariable logistic regression analysis indicated that Ang2 was a significant independent predictor for short-term mortality (odds ratio 18.75, P=0.033, 95% confidence interval 8.08-102.33). Ang1 was negatively correlated with Ang2 (P=0.032, Pearson's correlation coefficient =-0.317) and was positively correlated with vascular endothelial growth factor (P=0.019, Pearson's correlation coefficient = 0.359).
Ang2 might serve as a therapeutic and prognostic target for valvular heart disease.
目前针对心脏瓣膜病的循环生物标志物较少。血管生成素 (Ang) 1、Ang2 和血管内皮生长因子是重要的与炎症相关的细胞因子。本研究旨在探讨 Ang1、Ang2 和血管内皮生长因子在心脏瓣膜病中的临床意义及相关性。
这是一项回顾性研究，共纳入 62 人（心脏瓣膜病患者 [n=42] 和健康对照者 [n=20]）。采用酶联免疫吸附试验检测血浆 Ang1、Ang2 和血管内皮生长因子水平。我们回顾性收集了基线特征和短期预后数据；采用 logistic 回归分析确定短期死亡率的预测因素。
与健康对照组相比，心脏瓣膜病组的 Ang2 水平显著降低（P=0.023），而 Ang1 和血管内皮生长因子水平无显著差异。纽约心脏病协会（NYHA）心功能 I/II 级患者的 Ang2 水平（但 NYHA III/IV 级患者的 Ang2 水平无差异）显著低于健康对照组（NYHA I/II 级：P=0.017；NYHA III/IV 级：P=0.485）。单变量 logistic 回归分析表明，Ang2 是短期死亡率的独立显著预测因素（比值比 18.75，P=0.033，95%置信区间 8.08-102.33）。Ang1 与 Ang2 呈负相关（P=0.032，Pearson 相关系数=-0.317），与血管内皮生长因子呈正相关（P=0.019，Pearson 相关系数=0.359）。
Ang2 可能是心脏瓣膜病的治疗和预后靶点。
