Spradling Philip R, Xing Jian, Williams Roxanne, Masunu-Faleafaga Yolanda, Dulski Theresa, Mahamud Abdirahman, Drobeniuc Jan, Teshale Eyasu H
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Clin Vaccine Immunol. 2013 Apr;20(4):559-61. doi: 10.1128/CVI.00694-12. Epub 2013 Feb 13.
Most persons who receive hepatitis B vaccine during infancy will have a level of antibody to hepatitis B surface antigen (anti-HBsAg) of <10 IU/liter 10 to 15 years later; however, most will demonstrate immune memory by an anamnestic response to a vaccine challenge dose. To determine whether there was a difference in anamnestic response among college students vaccinated during infancy, we compared anti-HBsAg levels after a 20-μg dose of Engerix-B in those with a residual anti-HBsAg level of 0 IU/liter and those with levels of 1 to 9 IU/liter. Anti-HBsAg was measured before (baseline) and 2 weeks after a challenge dose; a response was defined as a level of ≥10 IU/liter after the dose among those with <10 IU/liter at the baseline. Of the 153 students who completed the study, 130 (85%) had an anti-HBsAg level of <10 IU/liter at the baseline, 72 had a level of 0 IU/liter, and 58 had levels ranging from 1 to 9 IU/liter. Students with a levels of 1 to 9 IU/liter were more likely to respond to the challenge dose than those with a baseline anti-HBsAg level of 0 IU/liter (83% versus 50%; P < 0.001). The presence of any detectable anti-HBsAg among persons vaccinated in the remote past may indicate the persistence of immune memory.
大多数在婴儿期接种乙肝疫苗的人在10至15年后乙肝表面抗原抗体（抗-HBsAg）水平会低于10国际单位/升；然而，大多数人通过对疫苗激发剂量的回忆反应表现出免疫记忆。为了确定婴儿期接种疫苗的大学生在回忆反应上是否存在差异，我们比较了接种20微克安在时力（Engerix-B）后，残余抗-HBsAg水平为0国际单位/升和1至9国际单位/升的人群的抗-HBsAg水平。在激发剂量前（基线）和激发剂量后2周测量抗-HBsAg；对于基线水平低于10国际单位/升的人群，反应定义为激发剂量后水平≥10国际单位/升。在完成研究的153名学生中，130名（85%）在基线时抗-HBsAg水平低于10国际单位/升，72名水平为0国际单位/升，58名水平在1至9国际单位/升之间。基线抗-HBsAg水平为1至9国际单位/升的学生比基线抗-HBsAg水平为0国际单位/升的学生更有可能对激发剂量产生反应（83%对50%；P<0.001）。在很久以前接种疫苗的人群中，任何可检测到的抗-HBsAg的存在可能表明免疫记忆的持续存在。
